Amir F Merican:Projects

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TITLE: Oral Transcriptome Mapping


To characterize the oral cancer Transcriptome in identifying the differentially express genes and novel mutations in oral cancer samples.

The research of Oral transcriptoming mapping was conducted by University of Malaya’s Oral Cancer Research & Coordinating Centre (UM-OCRCC) collaborators which are Ministry of Health (MOH), Cancer Research Initiatives Foundation (CARIF) and CRYSTAL of University of Malaya. Analysis on transcriptomics data carried out to select subset of genes differentially expressed in smokers and non smokers patients with different outcomes. Newly developed next-generation sequencing technologies with massive parallel sequencing-by-synthesis approach offer a highly robust, accurate, cost effective, higher depth and rapid results. Ilumina sequencing technology was used characterize the Transcriptome of oral cancer and normal samples and subsequently performed informatics analysis to identify the differentially expressing genes and mutation in cancer samples. This approach will provide detail molecular understanding of the mechanism underlying the development and progression of oral diseases and disorders, thus allowing better understanding of the complexities of transcriptional regulation and dysregulation in normal and cancerous tissues. Discovery of mechanisms underlying in biological pathway and processes related to oral cancer can helps to better understand interrelations among the observed differentially expressed genes. Analytical method and skills of bioinformatics are required for this research. It will also promote the exploration of possible anticancer targets and prognostic/diagnostic biomarkers.

TITLE: Three-dimensional analysis for craniofacial anomalies: A non-invasive study


1) To obtain quantitative information concerning the three-dimensional (3D) arrangement of the craniofacial features of subjects with craniofacial anomalies in Malaysia

2) To compare the craniofacial features of craniofacial anomalies patients with normal subjects in Malaysia

3) To develop a database that will store all 3D images of the study subjects with craniofacial anomalies in Malaysia

The aim of this study is to apply new visualization method to the analysis of craniofacial anomalies found in various syndromes. This project describes the three-dimensional (3D) assessment of craniofacial anomalies by using 3D images capturing systems which are non-invasive for human body. The 3D images will be captured using a Di3D Capture System and Vectra 3D Imaging. The craniofacial morphology of the subjects will be analyzed using DiView and Mirror software based on cephalometric landmark points in three-dimensions.