Aging bacteria

A portal for links, people, research and developments in bacterial and prokaryote aging. Please feel free to join, edit and contribute to the ideas, labs and publications. News 8.13.06 Aging bacteria section started on oww

Ideas Aging iGEM project - coming soon

Labs of interest Martin Akkerman Thomas Nystrom Eric Stewart Jonathan Visick Tamara's lab

Other resources aging in E.Coli (Visick lab)

Publications of interest Ackermann M, Stearns SC, and Jenal U. Senescence in a bacterium with asymmetric division. Science. 2003 Jun 20;300(5627):1920. DOI:10.1126/science.1083532 | Stewart EJ, Madden R, Paul G, and Taddei F. Aging and death in an organism that reproduces by morphologically symmetric division. PLoS Biol. 2005 Feb;3(2):e45. DOI:10.1371/journal.pbio.0030045 | Nyström T. Aging in bacteria. Curr Opin Microbiol. 2002 Dec;5(6):596-601. DOI:10.1016/s1369-5274(02)00367-3 |

What is replicative senescence?

"Two fundamentally different aging phenomena have been described at the cellular level: 1) the gradual decline of life processes in postmitotic cells, and, 2) the decline and eventual complete cessation of cell division observed in most replicating cell lineages. The former is measured in simple chronological time, and comes into play during the aging of postmitotic adult organisms, such as the nematode, or during the aging of largely postmitotic tissues such as the brain or muscle in more complex organisms. In contrast, finite replicative lifespan, often referred to as 'cellular replicative senescence', is measured in terms of cell divisions rather than chronological time. The current consensus is that both postmitotic and replicative aging processes are causally related to the aging of humans." source: John Sedivy

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