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<html> <align=left><h1 style="color:maroon">Publications: All</h1></align> <ol> <table width=120 border=0 cellpadding=0 cellspacing=0>

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                       <tr><td align="center"><a name="All">All</a></td></tr>
           <td width=0></td><td align="center"><a style="color:maroon; text-decoration:underline" href="">2006/07</a></td>

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           <td><a style="color:maroon; text-decoration:underline" href="">2005</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">2004</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">2003</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">2002</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">2001</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">2000</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1999</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1998</a></td>

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           </td><td><a style="color:maroon; text-decoration:underline" href="">1997</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1996</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1995</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1994</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1993</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1992</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1991</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">1990</a></td>

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           </td><td><a style="color:maroon; text-decoration:underline" href="">Pre'90</a></td>
           <td width=0></td><td><a style="color:maroon; text-decoration:underline" href="">Books</a></td>

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Publications accessible in PubMed

  1. Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, and Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol Cell Biol. 2007 Apr;27(8):2830-40. DOI:10.1128/MCB.00079-07 | PubMed ID:17283057 | HubMed [105]
  2. Alper H, Miyaoku K, and Stephanopoulos G. Characterization of lycopene-overproducing E. coli strains in high cell density fermentations. Appl Microbiol Biotechnol. 2006 Oct;72(5):968-74. DOI:10.1007/s00253-006-0357-y | PubMed ID:16502313 | HubMed [104]
  3. Fischer CR, Alper H, Nevoigt E, Jensen KL, and Stephanopoulos G. Response to Hammer et al.: Tuning genetic control--importance of thorough promoter characterization versus generating promoter diversity. Trends Biotechnol. 2006 Feb;24(2):55-6. DOI:10.1016/j.tibtech.2005.12.001 | PubMed ID:16380177 | HubMed [103]
  4. Jin YS, Alper H, Yang YT, and Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Appl Environ Microbiol. 2005 Dec;71(12):8249-56. DOI:10.1128/AEM.71.12.8249-8256.2005 | PubMed ID:16332810 | HubMed [102]
  5. Stephanopoulos G, Garefalaki ME, and Lyroudia K. Genes and related proteins involved in amelogenesis imperfecta. J Dent Res. 2005 Dec;84(12):1117-26. DOI:10.1177/154405910508401206 | PubMed ID:16304440 | HubMed [101]
  6. Raab RM, Tyo K, and Stephanopoulos G. Metabolic engineering. Adv Biochem Eng Biotechnol. 2005;100:1-17. DOI:10.1007/b136411 | PubMed ID:16270654 | HubMed [100]
  7. Lütke-Eversloh T and Stephanopoulos G. Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants. Appl Environ Microbiol. 2005 Nov;71(11):7224-8. DOI:10.1128/AEM.71.11.7224-7228.2005 | PubMed ID:16269762 | HubMed [99]
  8. Jensen KL, Styczynski MP, Rigoutsos I, and Stephanopoulos GN. A generic motif discovery algorithm for sequential data. Bioinformatics. 2006 Jan 1;22(1):21-8. DOI:10.1093/bioinformatics/bti745 | PubMed ID:16257985 | HubMed [98]
  9. Alper H, Fischer C, Nevoigt E, and Stephanopoulos G. Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12678-83. DOI:10.1073/pnas.0504604102 | PubMed ID:16123130 | HubMed [97]
  10. Raab RM, Bullen J, Kelleher J, Mantzoros C, and Stephanopoulos G. Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction. Nutr Metab (Lond). 2005 Jun 28;2:15. DOI:10.1186/1743-7075-2-15 | PubMed ID:15985155 | HubMed [96]
  11. Koffas M and Stephanopoulos G. Strain improvement by metabolic engineering: lysine production as a case study for systems biology. Curr Opin Biotechnol. 2005 Jun;16(3):361-6. DOI:10.1016/j.copbio.2005.04.010 | PubMed ID:15961038 | HubMed [95]
  12. Camelo S, Iglesias AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G, Assaf B, Langley B, Khoury SJ, Stephanopoulos G, De Girolami U, Ratan RR, Ferrante RJ, and Dangond F. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Jul;164(1-2):10-21. DOI:10.1016/j.jneuroim.2005.02.022 | PubMed ID:15885809 | HubMed [94]
  13. Alper H, Jin YS, Moxley JF, and Stephanopoulos G. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab Eng. 2005 May;7(3):155-64. DOI:10.1016/j.ymben.2004.12.003 | PubMed ID:15885614 | HubMed [93]
  14. Alper H, Miyaoku K, and Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol. 2005 May;23(5):612-6. DOI:10.1038/nbt1083 | PubMed ID:15821729 | HubMed [92]
  15. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V, and Inflammation and Host Response to Injury Large-Scale Collaborative Research Program.. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4801-6. DOI:10.1073/pnas.0409768102 | PubMed ID:15781863 | HubMed [91]
  16. Styczynski MP, Jensen KL, Rigoutsos I, and Stephanopoulos GN. An extension and novel solution to the (l,d)-motif challenge problem. Genome Inform. 2004;15(2):63-71. PubMed ID:15706492 | HubMed [90]
  17. Villas-Bôas SG, Moxley JF, Akesson M, Stephanopoulos G, and Nielsen J. High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts. Biochem J. 2005 Jun 1;388(Pt 2):669-77. DOI:10.1042/BJ20041162 | PubMed ID:15667247 | HubMed [89]
  18. Heijnen JJ, van Gulik WM, Shimizu H, and Stephanopoulos G. Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data. Metab Eng. 2004 Oct;6(4):391-400. DOI:10.1016/j.ymben.2004.07.002 | PubMed ID:15491867 | HubMed [88]
  19. Stephanopoulos G, Alper H, and Moxley J. Exploiting biological complexity for strain improvement through systems biology. Nat Biotechnol. 2004 Oct;22(10):1261-7. DOI:10.1038/nbt1016 | PubMed ID:15470466 | HubMed [87]
  20. Raab RM and Stephanopoulos G. Dynamics of gene silencing by RNA interference. Biotechnol Bioeng. 2004 Oct 5;88(1):121-32. DOI:10.1002/bit.20216 | PubMed ID:15389485 | HubMed [86]
  21. Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, and Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E662-70. DOI:10.1152/ajpendo.00114.2004 | PubMed ID:15361355 | HubMed [85]
  22. Schmitt WA Jr, Raab RM, and Stephanopoulos G. Elucidation of gene interaction networks through time-lagged correlation analysis of transcriptional data. Genome Res. 2004 Aug;14(8):1654-63. DOI:10.1101/gr.2439804 | PubMed ID:15289483 | HubMed [84]
  23. Lynch MD, Gill RT, and Stephanopoulos G. Mapping phenotypic landscapes using DNA micro-arrays. Metab Eng. 2004 Jul;6(3):177-85. DOI:10.1016/j.ymben.2004.01.002 | PubMed ID:15256207 | HubMed [83]
  24. Yoo H, Stephanopoulos G, and Kelleher JK. Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes. J Lipid Res. 2004 Jul;45(7):1324-32. DOI:10.1194/jlr.M400031-JLR200 | PubMed ID:15102881 | HubMed [82]
  25. Jung GY and Stephanopoulos G. A functional protein chip for pathway optimization and in vitro metabolic engineering. Science. 2004 Apr 16;304(5669):428-31. DOI:10.1126/science.1096920 | PubMed ID:15087547 | HubMed [81]
  26. Iglesias AH, Camelo S, Hwang D, Villanueva R, Stephanopoulos G, and Dangond F. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J Neuroimmunol. 2004 May;150(1-2):163-77. DOI:10.1016/j.jneuroim.2004.01.017 | PubMed ID:15081262 | HubMed [80]
  27. Hwang D, Stephanopoulos G, and Chan C. Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function. Bioinformatics. 2004 Mar 1;20(4):487-99. DOI:10.1093/bioinformatics/btg433 | PubMed ID:14990444 | HubMed [79]
  28. Lee K, Hwang D, Yokoyama T, Stephanopoulos G, Stephanopoulos GN, and Yarmush ML. Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics. 2004 Apr 12;20(6):959-69. DOI:10.1093/bioinformatics/bth015 | PubMed ID:14751977 | HubMed [78]
  29. Padilla L, Krämer R, Stephanopoulos G, and Agosin E. Overproduction of trehalose: heterologous expression of Escherichia coli trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in Corynebacterium glutamicum. Appl Environ Microbiol. 2004 Jan;70(1):370-6. DOI:10.1128/aem.70.1.370-376.2004 | PubMed ID:14711665 | HubMed [77]
  30. Schmitt WA Jr and Stephanopoulos G. Prediction of transcriptional profiles of Synechocystis PCC6803 by dynamic autoregressive modeling of DNA microarray data. Biotechnol Bioeng. 2003 Dec 30;84(7):855-63. DOI:10.1002/bit.10843 | PubMed ID:14708126 | HubMed [76]
  31. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Induction of a hypermetabolic state in cultured hepatocytes by glucagon and H2O2. Metab Eng. 2003 Oct;5(4):221-9. DOI:10.1016/s1096-7176(03)00042-9 | PubMed ID:14642350 | HubMed [75]
  32. Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH Jr, and Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiol Genomics. 2004 Jan 15;16(2):229-39. DOI:10.1152/physiolgenomics.00087.2001 | PubMed ID:14645737 | HubMed [74]
  33. Wong MS, Raab RM, Rigoutsos I, Stephanopoulos GN, and Kelleher JK. Metabolic and transcriptional patterns accompanying glutamine depletion and repletion in mouse hepatoma cells: a model for physiological regulatory networks. Physiol Genomics. 2004 Jan 15;16(2):247-55. DOI:10.1152/physiolgenomics.00088.2003 | PubMed ID:14612591 | HubMed [73]
  34. Klapa MI, Aon JC, and Stephanopoulos G. Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. Eur J Biochem. 2003 Sep;270(17):3525-42. DOI:10.1046/j.1432-1033.2003.03732.x | PubMed ID:12919317 | HubMed [72]
  35. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Profiling of dynamic changes in hypermetabolic livers. Biotechnol Bioeng. 2003 Aug 20;83(4):400-15. DOI:10.1002/bit.10682 | PubMed ID:12800135 | HubMed [71]
  36. Koffas MA, Jung GY, and Stephanopoulos G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab Eng. 2003 Jan;5(1):32-41. DOI:10.1016/s1096-7176(03)00002-8 | PubMed ID:12749842 | HubMed [70]
  37. Klapa MI, Aon JC, and Stephanopoulos G. Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination. Biotechniques. 2003 Apr;34(4):832-6, 838, 840 passim. DOI:10.2144/03344pt02 | PubMed ID:12703309 | HubMed [69]
  38. Chan C, Hwang D, Stephanopoulos GN, Yarmush ML, and Stephanopoulos G. Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnol Prog. 2003 Mar-Apr;19(2):580-98. DOI:10.1021/bp025660h | PubMed ID:12675604 | HubMed [68]
  39. Hwang D, Alevizos I, Schmitt WA, Misra J, Ohyama H, Todd R, Mahadevappa M, Warrington JA, Stephanopoulos G, Wong DT, and Stephanopoulos G. Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncol. 2003 Apr;39(3):259-68. DOI:10.1016/s1368-8375(02)00108-2 | PubMed ID:12618198 | HubMed [67]
  40. Varela C, Agosin E, Baez M, Klapa M, and Stephanopoulos G. Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress. Appl Microbiol Biotechnol. 2003 Jan;60(5):547-55. DOI:10.1007/s00253-002-1120-7 | PubMed ID:12536254 | HubMed [66]
  41. Koffas MA, Jung GY, Aon JC, and Stephanopoulos G. Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Appl Environ Microbiol. 2002 Nov;68(11):5422-8. DOI:10.1128/aem.68.11.5422-5428.2002 | PubMed ID:12406733 | HubMed [65]
  42. Hwang D, Schmitt WA, Stephanopoulos G, and Stephanopoulos G. Determination of minimum sample size and discriminatory expression patterns in microarray data. Bioinformatics. 2002 Sep;18(9):1184-93. DOI:10.1093/bioinformatics/18.9.1184 | PubMed ID:12217910 | HubMed [64]
  43. Stephanopoulos G, Hwang D, Schmitt WA, Misra J, and Stephanopoulos G. Mapping physiological states from microarray expression measurements. Bioinformatics. 2002 Aug;18(8):1054-63. DOI:10.1093/bioinformatics/18.8.1054 | PubMed ID:12176828 | HubMed [63]
  44. Misra J, Schmitt W, Hwang D, Hsiao LL, Gullans S, Stephanopoulos G, and Stephanopoulos G. Interactive exploration of microarray gene expression patterns in a reduced dimensional space. Genome Res. 2002 Jul;12(7):1112-20. DOI:10.1101/gr.225302 | PubMed ID:12097349 | HubMed [62]
  45. Stephanopoulos G. Metabolic engineering by genome shuffling. Nat Biotechnol. 2002 Jul;20(7):666-8. DOI:10.1038/nbt0702-666 | PubMed ID:12089547 | HubMed [61]
  46. Gill RT, Katsoulakis E, Schmitt W, Taroncher-Oldenburg G, Misra J, and Stephanopoulos G. Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803. J Bacteriol. 2002 Jul;184(13):3671-81. DOI:10.1128/jb.184.13.3671-3681.2002 | PubMed ID:12057963 | HubMed [60]
  47. Gill RT, Wildt S, Yang YT, Ziesman S, and Stephanopoulos G. Genome-wide screening for trait conferring genes using DNA microarrays. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7033-8. DOI:10.1073/pnas.102154799 | PubMed ID:11997466 | HubMed [59]
  48. Stafford DE, Yanagimachi KS, Lessard PA, Rijhwani SK, Sinskey AJ, and Stephanopoulos G. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1801-6. DOI:10.1073/pnas.032681699 | PubMed ID:11854482 | HubMed [58]
  49. Follstad BD, Wang DI, and Stephanopoulos G. Mitochondrial membrane potential selects hybridomas yielding high viability in fed-batch cultures. Biotechnol Prog. 2002 Jan-Feb;18(1):1-5. DOI:10.1021/bp010132b | PubMed ID:11822893 | HubMed [57]
  50. Stafford DE, Yanagimachi KS, and Stephanopoulos G. Metabolic engineering of indene bioconversion in Rhodococcus sp. Adv Biochem Eng Biotechnol. 2001;73:85-101. DOI:10.1007/3-540-45300-8_5 | PubMed ID:11816813 | HubMed [56]
  51. Stephanopoulos G and Gill RT. After a decade of progress, an expanded role for metabolic engineering. Adv Biochem Eng Biotechnol. 2001;73:1-8. DOI:10.1007/3-540-45300-8_1 | PubMed ID:11816808 | HubMed [55]
  52. Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, MacDonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopoulos G, and Gullans SR. A compendium of gene expression in normal human tissues. Physiol Genomics. 2001 Dec 21;7(2):97-104. DOI:10.1152/physiolgenomics.00040.2001 | PubMed ID:11773596 | HubMed [54]
  53. Walton SP, Stephanopoulos GN, Yarmush ML, and Roth CM. Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA. Biophys J. 2002 Jan;82(1 Pt 1):366-77. DOI:10.1016/S0006-3495(02)75401-5 | PubMed ID:11751323 | HubMed [53]
  54. Koffas M, Roberge C, Lee K, and Stephanopoulos G. Metabolic engineering. Annu Rev Biomed Eng. 1999;1:535-57. DOI:10.1146/annurev.bioeng.1.1.535 | PubMed ID:11701499 | HubMed [52]
  55. Yanagimachi KS, Stafford DE, Dexter AF, Sinskey AJ, Drew S, and Stephanopoulos G. Application of radiolabeled tracers to biocatalytic flux analysis. Eur J Biochem. 2001 Sep;268(18):4950-60. DOI:10.1046/j.0014-2956.2001.02426.x | PubMed ID:11559364 | HubMed [51]
  56. Stephanopoulos G and Kelleher J. Biochemistry. How to make a superior cell. Science. 2001 Jun 15;292(5524):2024-5. DOI:10.1126/science.1062556 | PubMed ID:11408647 | HubMed [50]
  57. Balcarcel RR and Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnol Bioeng. 2001;76(1):1-10. DOI:10.1002/bit.1020 | PubMed ID:11400101 | HubMed [49]
  58. Stafford DE and Stephanopoulos G. Metabolic engineering as an integrating platform for strain development. Curr Opin Microbiol. 2001 Jun;4(3):336-40. DOI:10.1016/s1369-5274(00)00214-9 | PubMed ID:11378489 | HubMed [48]
  59. Lee K, Berthiaume F, Stephanopoulos GN, Yarmush DM, and Yarmush ML. Metabolic flux analysis of postburn hepatic hypermetabolism. Metab Eng. 2000 Oct;2(4):312-27. DOI:10.1006/mben.2000.0160 | PubMed ID:11120643 | HubMed [47]
  60. Kamimura RT, Bicciato S, Shimizu H, Alford J, and Stephanopoulos G. Mining of biological data II: assessing data structure and class homogeneity by cluster analysis. Metab Eng. 2000 Jul;2(3):228-38. DOI:10.1006/mben.2000.0155 | PubMed ID:11056065 | HubMed [46]
  61. Kamimura RT, Bicciato S, Shimizu H, Alford J, and Stephanopoulos G. Mining of biological data I: identifying discriminating features via mean hypothesis testing. Metab Eng. 2000 Jul;2(3):218-27. DOI:10.1006/mben.2000.0154 | PubMed ID:11056064 | HubMed [45]
  62. Stephanopoulos G. Bioinformatics and metabolic engineering. Metab Eng. 2000 Jul;2(3):157-8. DOI:10.1006/mben.2000.0157 | PubMed ID:11056058 | HubMed [44]
  63. Follstad BD, Wang DI, and Stephanopoulos G. Mitochondrial membrane potential differentiates cells resistant to apoptosis in hybridoma cultures. Eur J Biochem. 2000 Nov;267(22):6534-40. DOI:10.1046/j.1432-1327.2000.01743.x | PubMed ID:11054104 | HubMed [43]
  64. Sanfeliu A, Chung JD, and Stephanopoulos G. Effect of insulin stimulation on the proliferation and death of Chinese hamster ovary cells. Biotechnol Bioeng. 2000 Nov 20;70(4):421-7. DOI:10.1002/1097-0290(20001120)70:4<421::aid-bit7>;2-s | PubMed ID:11005924 | HubMed [42]
  65. Stephanopoulos G. Metabolic fluxes and metabolic engineering. Metab Eng. 1999 Jan;1(1):1-11. DOI:10.1006/mben.1998.0101 | PubMed ID:10935750 | HubMed [41]
  66. Shanks JV and Stephanopoulos G. Biochemical engineering. Bridging the gap between gene and product. Curr Opin Biotechnol. 2000 Apr;11(2):169-70. DOI:10.1016/s0958-1669(00)00076-8 | PubMed ID:10809544 | HubMed [40]
  67. Vallino JJ and Stephanopoulos G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Reprinted from Biotechnology and Bioengineering, Vol. 41, Pp 633-646 (1993). Biotechnol Bioeng. 2000 Mar 20;67(6):872-85. PubMed ID:10699864 | HubMed [39]
  68. Simpson TW, Follstad BD, and Stephanopoulos G. Analysis of the pathway structure of metabolic networks. J Biotechnol. 1999 May 28;71(1-3):207-23. DOI:10.1016/s0168-1656(99)00023-1 | PubMed ID:10483107 | HubMed [38]
  69. Lee K, Berthiaume F, Stephanopoulos GN, and Yarmush ML. Metabolic flux analysis: a powerful tool for monitoring tissue function. Tissue Eng. 1999 Aug;5(4):347-68. DOI:10.1089/ten.1999.5.347 | PubMed ID:10477857 | HubMed [37]
  70. Walton SP, Stephanopoulos GN, Yarmush ML, and Roth CM. Prediction of antisense oligonucleotide binding affinity to a structured RNA target. Biotechnol Bioeng. 1999 Oct 5;65(1):1-9. PubMed ID:10440665 | HubMed [36]
  71. Treadway SL, Yanagimachi KS, Lankenau E, Lessard PA, Stephanopoulos G, and Sinskey AJ. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl Microbiol Biotechnol. 1999 Jun;51(6):786-93. DOI:10.1007/s002530051463 | PubMed ID:10422226 | HubMed [35]
  72. Sanfeliu A and Stephanopoulos G. Effect of glutamine limitation on the death of attached Chinese hamster ovary cells. Biotechnol Bioeng. 1999 Jul 5;64(1):46-53. PubMed ID:10397838 | HubMed [34]
  73. Follstad BD, Balcarcel RR, Stephanopoulos G, and Wang DI. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnol Bioeng. 1999 Jun 20;63(6):675-83. DOI:10.1002/(sici)1097-0290(19990620)63:6<675::aid-bit5>;2-r | PubMed ID:10397824 | HubMed [33]
  74. Shaw-Reid CA, McCormick MM, Sinskey AJ, and Stephanopoulos G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Appl Microbiol Biotechnol. 1999 Mar;51(3):325-33. DOI:10.1007/s002530051398 | PubMed ID:10222581 | HubMed [32]
  75. Simpson TW, Shimizu H, and Stephanopoulos G. Experimental determination of group flux control coefficients in metabolic networks . Biotechnol Bioeng. 1998 Apr 5;58(2-3):149-53. DOI:10.1002/(sici)1097-0290(19980420)58:2/3<149::aid-bit6>;2-l | PubMed ID:10191384 | HubMed [31]
  76. Stephanopoulos G. Metabolic engineering. Biotechnol Bioeng. 1998 Apr 20-May 5;58(2-3):119-20. PubMed ID:10191379 | HubMed [30]
  77. Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, and Wang DI. Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells. Biotechnol Bioeng. 1999 Feb 5;62(3):336-47. DOI:10.1002/(sici)1097-0290(19990205)62:3<336::aid-bit10>;2-n | PubMed ID:10099545 | HubMed [29]
  78. Nyberg GB, Balcarcel RR, Follstad BD, Stephanopoulos G, and Wang DI. Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium. Biotechnol Bioeng. 1999 Feb 5;62(3):324-35. PubMed ID:10099544 | HubMed [28]
  79. Chung JD, Sinskey AJ, and Stephanopoulos G. Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line. Biotechnol Bioeng. 1998 Jan 20;57(2):164-71. PubMed ID:10099191 | HubMed [27]
  80. Klapa MI, Park SM, Sinskey AJ, and Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol Bioeng. 1999 Feb;62(4):375-391. DOI:10.1002/(sici)1097-0290(19990220)62:4<375::aid-bit1>;2-o | PubMed ID:10099550 | HubMed [26]
  81. Goswami J, Sinskey AJ, Steller H, Stephanopoulos GN, and Wang DI. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol Bioeng. 1999 Mar 20;62(6):632-40. DOI:10.1002/(sici)1097-0290(19990320)62:6<632::aid-bit2>;2-i | PubMed ID:9951521 | HubMed [25]
  82. Park SM, Klapa MI, Sinskey AJ, and Stephanopoulos G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng. 1999 Feb 20;62(4):392-401. DOI:10.1002/(sici)1097-0290(19990220)62:4<392::aid-bit2>;2-s | PubMed ID:9921151 | HubMed [24]
  83. Koffas MA, Ramamoorthi R, Pine WA, Sinskey AJ, and Stephanopoulos G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl Microbiol Biotechnol. 1998 Sep;50(3):346-52. DOI:10.1007/s002530051302 | PubMed ID:9802220 | HubMed [23]
  84. Follstad BD and Stephanopoulos G. Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway. Eur J Biochem. 1998 Mar 15;252(3):360-71. DOI:10.1046/j.1432-1327.1998.2520360.x | PubMed ID:9546650 | HubMed [22]
  85. Grampp GE, Applegate MA, and Stephanopoulos G. Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone. A comparison of single-pass and recycle modes of operation. Biotechnol Prog. 1996 Nov-Dec;12(6):837-46. DOI:10.1021/bp960066r | PubMed ID:8983208 | HubMed [21]
  86. Kamimura R, Konstantinov K, and Stephanopoulos G. Knowledge-based systems, artificial neural networks and pattern recognition: applications to biotechnological processes. Curr Opin Biotechnol. 1996 Apr;7(2):231-4. DOI:10.1016/s0958-1669(96)80018-8 | PubMed ID:8791334 | HubMed [20]
  87. Zupke C, Sinskey AJ, and Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. DOI:10.1007/BF00164476 | PubMed ID:8579834 | HubMed [19]
  88. Chen K, Stephanopoulos GN, Sinskey AJ, and Lodish HF. Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3. Biotechnology (N Y). 1995 Nov;13(11):1191-7. DOI:10.1038/nbt1195-1191 | PubMed ID:9636291 | HubMed [18]
  89. Chung JD, Conner S, and Stephanopoulos G. Flow cytometric study of differentiating cultures of Bacillus subtilis. Cytometry. 1995 Aug 1;20(4):324-33. DOI:10.1002/cyto.990200408 | PubMed ID:7587720 | HubMed [17]
  90. Colón GE, Nguyen TT, Jetten MS, Sinskey AJ, and Stephanopoulos G. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Appl Microbiol Biotechnol. 1995 Jul;43(3):482-8. DOI:10.1007/BF00218453 | PubMed ID:7632398 | HubMed [16]
  91. Simpson TW, Colón GE, and Stephanopoulos G. Two paradigms of metabolic engineering applied to amino acid biosynthesis. Biochem Soc Trans. 1995 May;23(2):381-7. DOI:10.1042/bst0230381 | PubMed ID:7672413 | HubMed [15]
  92. Colón GE, Jetten MS, Nguyen TT, Gubler ME, Follettie MT, Sinskey AJ, and Stephanopoulos G. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Appl Environ Microbiol. 1995 Jan;61(1):74-8. DOI:10.1128/AEM.61.1.74-78.1995 | PubMed ID:7887627 | HubMed [14]
  93. Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wang DI, Whitesides GM, and Ingber DE. Engineering cell shape and function. Science. 1994 Apr 29;264(5159):696-8. DOI:10.1126/science.8171320 | PubMed ID:8171320 | HubMed [13]
  94. Chung JD, Stephanopoulos G, Ireton K, and Grossman AD. Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation. J Bacteriol. 1994 Apr;176(7):1977-84. DOI:10.1128/jb.176.7.1977-1984.1994 | PubMed ID:8144465 | HubMed [12]
  95. Stephanopoulos G. Metabolic engineering. Curr Opin Biotechnol. 1994 Feb;5(2):196-200. DOI:10.1016/s0958-1669(05)80036-9 | PubMed ID:7764800 | HubMed [11]
  96. Shelikoff M, Sinskey AJ, and Stephanopoulos G. The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin. Cytotechnology. 1994;15(1-3):195-208. DOI:10.1007/BF00762394 | PubMed ID:7765932 | HubMed [10]
  97. Stephanopoulos G and Sinskey AJ. Metabolic engineering--methodologies and future prospects. Trends Biotechnol. 1993 Sep;11(9):392-6. DOI:10.1016/0167-7799(93)90099-U | PubMed ID:7764086 | HubMed [9]
  98. Grampp GE and Stephanopoulos G. Development and scaleup of controlled secretion processes for improved product recovery in animal cell culture. Ann N Y Acad Sci. 1992 Oct 13;665:81-93. DOI:10.1111/j.1749-6632.1992.tb42576.x | PubMed ID:1416622 | HubMed [8]
  99. Kennedy MJ, Thakur MS, Wang DI, and Stephanopoulos GN. Techniques for the estimation of cell concentration in the presence of suspended solids. Biotechnol Prog. 1992 Sep-Oct;8(5):375-81. DOI:10.1021/bp00017a001 | PubMed ID:1369219 | HubMed [7]
  100. Grampp GE, Sambanis A, and Stephanopoulos GN. Use of regulated secretion in protein production from animal cells: an overview. Adv Biochem Eng Biotechnol. 1992;46:35-62. DOI:10.1007/BFb0000704 | PubMed ID:1636482 | HubMed [6]
  101. Stephanopoulos G and Vallino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science. 1991 Jun 21;252(5013):1675-81. DOI:10.1126/science.1904627 | PubMed ID:1904627 | HubMed [5]
  102. Sambanis A, Stephanopoulos G, and Lodish HF. Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells. Cytotechnology. 1990 Sep;4(2):111-9. DOI:10.1007/BF00365091 | PubMed ID:1367038 | HubMed [4]
  103. Vallino JJ and Stephanopoulos GN. Intelligent sensors in biotechnology. Applications for the monitoring of fermentations and cellular metabolism. Ann N Y Acad Sci. 1987;506:415-30. DOI:10.1111/j.1749-6632.1987.tb23838.x | PubMed ID:3324860 | HubMed [3]
  104. Fredrickson AG and Stephanopoulos G. Microbial competition. Science. 1981 Aug 28;213(4511):972-9. DOI:10.1126/science.7268409 | PubMed ID:7268409 | HubMed [2]
  105. Stephanopoulos G, Schuelke LM, and Stephanopoulos G. A decomposition method for the stability analysis of large microbial systems. Theor Popul Biol. 1979 Oct;16(2):126-43. DOI:10.1016/0040-5809(79)90009-1 | PubMed ID:538730 | HubMed [1]

All Medline abstracts: PubMed | HubMed

Publications in other databases

A good place to check for other publications is the Web of Science.

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