Academic Program: Workshop in Biomedicine

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Workshop in Biomedicine Santander, January 21 to February 1, 2007

Coordinator: Prof. Fernando de la Cruz (

All lectures will take place in the School of Medicine, University of Cantabria, Aula 9, from 4.30 PM to 7.30 PM, except on Thursday, January 24, that will be from 10 AM to 1 PM).


Monday, January 21

Dr. Javier Martínez Botas Hospital Ramón y Cajal, Madrid The use of focused microarrays in Biomedicine (5, 19)

Tuesday, January 22

Dr. Vicente Rubio Instituto de Biomedicina de Valencia, CSIC, Valencia Structural biology and the advent of molecular medicine (1, 14)

Wednesday, January 23

Dra. Antonia Herrero Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC – Universidad de Sevilla Transcriptional regulation and cell differentiation in cyanobacteria (8, 15)

Thursday, January 24

Prof. Javier León Universidad de Cantabria, Santander The genesis of blood cancer (17)

Dr. Mariano Barbacid CNIO, Madrid. Ras genes, Ras oncogenes and Cancer (11)

Friday, January 25

Prof. Antonio Gómez Muñoz Universidad del País Vasco, Bilbao Cell signalling through bioactive lipids (9, 10)

Monday, January 28

Prof. Fernando de la Cruz Universidad de Cantabria, Santander The end of the oil era (6)

Dr. Gabriel Moncalián Universidad de Cantabria, Santander Microbial obesity: The biosynthesis of Triacylglycerol in Bacteria (20)

Tuesday, January 29

Dr. Javier Urchueguía Universidad Politécnica de Valencia Synthetic Biology, a novel approach in the boundary between biology and engineering (4, 7, 16)

Wednesday, January 30

Prof. José Carlos Rodríguez Rey Universidad de Cantabria, Santander Genetic polymorphisms in transcription control regions. Application to the study of the genetic basis of common diseases (12, 18)

Thursday, January 31

Dr. Irantzu Bernales Universidad del País Vasco, Bilbao Genomic Technologies: uses and applications of microarray technologies and Real Time PCR (3, 13)

Friday, February 1

Dr. Diego di Bernardo Telethon Institute of Genetics and Medicine, Naples (Italy) Reverse Engineering and modelling of complex gene regulatory networks (2)

Nota respecto a la evaluación de los alumnos

a) Todo el mundo tiene un 7/10 de partida.

b) Esa nota se puede bajar por faltas de asistencia (aprox. 0,5 puntos por falta). A tal efecto, habrá que firmar cada día en una hoja de asistencia, que se pasará al principio de la clase.

c) La nota se puede subir por participación activa en clase, y por la calificación del trabajo final. Este debe tener 3-5 hojas, estar redactado en ingles, y versar sobre uno cualquiera de los temas tratados en el curso. Se pondrá particular interés en el formato de las citas (tiene que haber un mínimo de cinco citas), que debe ser uniforme, en el estilo de cualquier revista científica.


1. Arranz, J. A., E. Riudor, C. Marco-Marin, and V. Rubio. 2007. Estimation of the total number of disease-causing mutations in ornithine transcarbamylase (OTC) deficiency. Value of the OTC structure in predicting a mutation pathogenic potential. J Inherit Metab Dis 30:217-26. Media:Arranz.ogg

2. Bansal, M., V. Belcastro, A. Ambesi-Impiombato, and D. di Bernardo. 2007. How to infer gene networks from expression profiles. Mol Syst Biol 3:78. File:Bansal.jpg

3. Bernardini, M., C. H. Lee, B. Beheshti, M. Prasad, M. Albert, P. Marrano, H. Begley, P. Shaw, A. Covens, J. Murphy, B. Rosen, S. Minkin, J. A. Squire, and P. F. Macgregor. 2005. High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer. Neoplasia 7:603-13. File:Bernardini.jpg

4. Bulter, T., S. G. Lee, W. W. Wong, E. Fung, M. R. Connor, and J. C. Liao. 2004. Design of artificial cell-cell communication using gene and metabolic networks. Proc Natl Acad Sci U S A 101:2299-304. File:Bulter.jpg

5. Castro-Chavez, F., V. K. Yechoor, P. K. Saha, J. Martinez-Botas, E. C. Wooten, S. Sharma, P. O'Connell, H. Taegtmeyer, and L. Chan. 2003. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes 52:2666-74. File:Castro-Chavez.jpg

6. Deffeyes, K. S. 2005. Beyond oil : the view from Hubbert's Peak. Hill and Wang, New York, N.Y.,+K.+S.+2005.+Beyond+oil+:+the+view+from+Hubbert%27s+Peak.+Hill+and+Wang&btnG=Buscar&sa=X&oi=print&ct=title&cad=one-book-with-thumbnail#PPP2,M1

7. Elowitz, M. B., and S. Leibler. 2000. A synthetic oscillatory network of transcriptional regulators. Nature 403:335-8. File:Elowitz.jpg

8. Flores, E., A. Herrero, C. P. Wolk, and I. Maldener. 2006. Is the periplasm continuous in filamentous multicellular cyanobacteria? Trends Microbiol 14:439-43. File:Flores.jpg

9. Gomez-Munoz, A_1. 2006. Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim Biophys Acta 1758:2049-56. File:Gomez-Munoz.jpg

10. Gomez-Munoz, A_2. 1998. Modulation of cell signalling by ceramides. Biochim Biophys Acta 1391:92-109. File:Gomez-Munoz 2.jpg

11. Guerra, C., A. J. Schuhmacher, M. Canamero, P. J. Grippo, L. Verdaguer, L. Perez-Gallego, P. Dubus, E. P. Sandgren, and M. Barbacid. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11:291-302. File:Guerra.jpg

12. Knight, J. C. 2005. Regulatory polymorphisms underlying complex disease traits. J Mol Med 83:97-109. File:Knight.jpg

13. Lee, T. I., R. G. Jenner, L. A. Boyer, M. G. Guenther, S. S. Levine, R. M. Kumar, B. Chevalier, S. E. Johnstone, M. F. Cole, K. Isono, H. Koseki, T. Fuchikami, K. Abe, H. L. Murray, J. P. Zucker, B. Yuan, G. W. Bell, E. Herbolsheimer, N. M. Hannett, K. Sun, D. T. Odom, A. P. Otte, T. L. Volkert, D. P. Bartel, D. A. Melton, D. K. Gifford, R. Jaenisch, and R. A. Young. 2006. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301-13. Lee.jpg

14. Llacer, J. L., A. Contreras, K. Forchhammer, C. Marco-Marin, F. Gil-Ortiz, R. Maldonado, I. Fita, and V. Rubio. 2007. The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. Proc Natl Acad Sci U S A 104:17644-9. File:Lacer.jpg

15. Mariscal, V., A. Herrero, and E. Flores. 2007. Continuous periplasm in a filamentous, heterocyst-forming cyanobacterium. Mol Microbiol 65:1139-45. File:Mariscal.jpg

16. McDaniel, R., and R. Weiss. 2005. Advances in synthetic biology: on the path from prototypes to applications. Curr Opin Biotechnol 16:476-83. File:McDanial.jpg

17. Munoz-Alonso, M. J., J. C. Acosta, C. Richard, M. D. Delgado, J. Sedivy, and J. Leon. 2005. p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells. J Biol Chem 280:18120-9. File:Munoz-Alonso.jpg

18. Pampin, S., and J. C. Rodriguez-Rey. 2007. Functional analysis of regulatory single-nucleotide polymorphisms. Curr Opin Lipidol 18:194-8. File:Pampin.jpg

19. Pollack, J. R., and V. R. Iyer. 2002. Characterizing the physical genome. Nat Genet 32 Suppl:515-21. File:Pollack.jpg

20. Waltermann, M., A. Hinz, H. Robenek, D. Troyer, R. Reichelt, U. Malkus, H. J. Galla, R. Kalscheuer, T. Stoveken, P. von Landenberg, and A. Steinbuchel. 2005. Mechanism of lipid-body formation in prokaryotes: how bacteria fatten up. Mol Microbiol 55:750-63. File:Walterman.jpg