User:Wayne G. Shreffler

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Contact Info

Wayne G. Shreffler

Wayne G. Shreffler, MD, PhD

MassGeneral Hospital for Children &

MGH, Center for Immunology and Inflammatory Diseases

Bldg. 149-13th St. Rm. 8312

Charlestown MA 02129



  • 1998, MD, New York University
  • 1997, PhD, New York University
  • 1996, MS, New York University
  • 1991, BS, University of Washington

Research interests

  1. Mechanisms of Allergenicity
  2. Immune Tolerance and Food Allergy
  3. Mechanisms of Immediate Hypersensitivity and its Regulation


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PubMed Link

Selected Research Articles

  1. Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr;123(4):789-94.e20. DOI:10.1016/j.jaci.2008.12.1128 | PubMed ID:19348919 | HubMed [Paper1]
  2. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan;123(1):43-52.e7. DOI:10.1016/j.jaci.2008.09.051 | PubMed ID:19130927 | HubMed [Paper2]
  3. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar;121(3):737-743.e10. DOI:10.1016/j.jaci.2007.11.039 | PubMed ID:18234310 | HubMed [Paper3]
  4. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15;177(6):3677-85. PubMed ID:16951327 | HubMed [Paper4]
  5. Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct;116(4):893-9. DOI:10.1016/j.jaci.2005.06.033 | PubMed ID:16210066 | HubMed [Paper5]
  6. Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr;113(4):776-82. DOI:10.1016/j.jaci.2003.12.588 | PubMed ID:15100687 | HubMed [Paper6]
All Medline abstracts: PubMed | HubMed

Selected Review Articles

  1. Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009;524:259-72. DOI:10.1007/978-1-59745-450-6_19 | PubMed ID:19377951 | HubMed [Paper1]
  2. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb;123(2):352-3. DOI:10.1016/j.jaci.2008.12.1119 | PubMed ID:19203659 | HubMed [Paper2]
  3. Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov;101(5):544-9. DOI:10.1016/S1081-1206(10)60295-5 | PubMed ID:19055210 | HubMed [Paper3]
  4. Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun;121(6):1311-20; quiz 1321-2. DOI:10.1016/j.jaci.2008.04.023 | PubMed ID:18539190 | HubMed [Paper4]
  5. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):226-33. DOI:10.1097/01.all.0000225165.83144.2f | PubMed ID:16670519 | HubMed [Paper5]
All Medline abstracts: PubMed | HubMed


  1. Aceves SS, Newbury RO, Dohil MA, Bastian JF, and Dohil R. A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation. Ann Allergy Asthma Immunol. 2009 Nov;103(5):401-6. DOI:10.1016/S1081-1206(10)60359-6 | PubMed ID:19927538 | HubMed [Paper]
  2. Assa'ad A. Detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem. Ann Allergy Asthma Immunol. 2005 Oct;95(4):309-11. DOI:10.1016/S1081-1206(10)61145-3 | PubMed ID:16279557 | HubMed [Paper]
  3. Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, and Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005 Oct;95(4):336-43. DOI:10.1016/S1081-1206(10)61151-9 | PubMed ID:16279563 | HubMed [Paper]
  4. Spergel JM, Beausoleil J, Brown-Whitehorn T, and Liacouras CA. Authors' response to detection of causative foods by skin prick and atopy patch tests in patients with eosinophilic esophagitis: things are not what they seem. Ann Allergy Asthma Immunol. 2006 Feb;96(2):376-8. DOI:10.1016/S1081-1206(10)61252-5 | PubMed ID:16498864 | HubMed [Paper]
  5. Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, and Rothenberg ME. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9. DOI:10.1016/j.cgh.2008.01.004 | PubMed ID:18434257 | HubMed [Paper]
  6. Protheroe C, Woodruff SA, de Petris G, Mukkada V, Ochkur SI, Janarthanan S, Lewis JC, Pasha S, Lunsford T, Harris L, Sharma VK, McGarry MP, Lee NA, Furuta GT, and Lee JJ. A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2009 Jul;7(7):749-755.e11. DOI:10.1016/j.cgh.2009.03.022 | PubMed ID:19345285 | HubMed [Paper]
  7. Prasad GA, Alexander JA, Schleck CD, Zinsmeister AR, Smyrk TC, Elias RM, Locke GR 3rd, and Talley NJ. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol. 2009 Oct;7(10):1055-61. DOI:10.1016/j.cgh.2009.06.023 | PubMed ID:19577011 | HubMed [Paper]
  8. Dehlink E and Fiebiger E. The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009 Feb;29(1):159-70, xii. DOI:10.1016/j.iac.2008.09.004 | PubMed ID:19141351 | HubMed [Paper]
  9. Haas AM and Maune NC. Clinical presentation of feeding dysfunction in children with eosinophilic gastrointestinal disease. Immunol Allergy Clin North Am. 2009 Feb;29(1):65-75, ix. DOI:10.1016/j.iac.2008.09.014 | PubMed ID:19141342 | HubMed [Paper]
  10. Aceves SS and Ackerman SJ. Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. Immunol Allergy Clin North Am. 2009 Feb;29(1):197-211, xiii-xiv. DOI:10.1016/j.iac.2008.10.003 | PubMed ID:19141355 | HubMed [Paper]
  11. Chehade M and Sampson HA. The role of lymphocytes in eosinophilic gastrointestinal disorders. Immunol Allergy Clin North Am. 2009 Feb;29(1):149-58, xii. DOI:10.1016/j.iac.2008.10.006 | PubMed ID:19141350 | HubMed [Paper]
  12. Straumann A and Simon HU. Eosinophilic esophagitis: escalating epidemiology?. J Allergy Clin Immunol. 2005 Feb;115(2):418-9. DOI:10.1016/j.jaci.2004.11.006 | PubMed ID:15696105 | HubMed [Paper]
  13. Aceves SS, Newbury RO, Dohil R, Bastian JF, and Broide DH. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan;119(1):206-12. DOI:10.1016/j.jaci.2006.10.016 | PubMed ID:17208603 | HubMed [Paper]
  14. Spergel JM, Brown-Whitehorn T, Beausoleil JL, Shuker M, and Liacouras CA. Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Feb;119(2):509-11. DOI:10.1016/j.jaci.2006.11.016 | PubMed ID:17291865 | HubMed [Paper]
  15. Straumann A, Bussmann C, Conus S, Beglinger C, and Simon HU. Anti-TNF-alpha (infliximab) therapy for severe adult eosinophilic esophagitis. J Allergy Clin Immunol. 2008 Aug;122(2):425-7. DOI:10.1016/j.jaci.2008.06.012 | PubMed ID:18678345 | HubMed [Paper]
  16. Rondón C, Fernández J, López S, Campo P, Doña I, Torres MJ, Mayorga C, and Blanca M. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009 Nov;124(5):1005-11.e1. DOI:10.1016/j.jaci.2009.07.018 | PubMed ID:19796796 | HubMed [Paper]
  17. Prussin C, Lee J, and Foster B. Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses. J Allergy Clin Immunol. 2009 Dec;124(6):1326-32.e6. DOI:10.1016/j.jaci.2009.09.048 | PubMed ID:20004787 | HubMed [Paper]
  18. Shah A, Kagalwalla AF, Gonsalves N, Melin-Aldana H, Li BU, and Hirano I. Histopathologic variability in children with eosinophilic esophagitis. Am J Gastroenterol. 2009 Mar;104(3):716-21. DOI:10.1038/ajg.2008.117 | PubMed ID:19209168 | HubMed [Paper]
  19. Almansa C, Krishna M, Buchner AM, Ghabril MS, Talley N, DeVault KR, Wolfsen H, Raimondo M, Guarderas JC, and Achem SR. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009 Apr;104(4):828-33. DOI:10.1038/ajg.2008.169 | PubMed ID:19240704 | HubMed [Paper]
  20. Kephart GM, Alexander JA, Arora AS, Romero Y, Smyrk TC, Talley NJ, and Kita H. Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis. Am J Gastroenterol. 2010 Feb;105(2):298-307. DOI:10.1038/ajg.2009.584 | PubMed ID:19888203 | HubMed [Paper]
  21. Schoepfer AM, Gonsalves N, Bussmann C, Conus S, Simon HU, Straumann A, and Hirano I. Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation. Am J Gastroenterol. 2010 May;105(5):1062-70. DOI:10.1038/ajg.2009.657 | PubMed ID:19935783 | HubMed [Paper]
  22. Atkins D, Kramer R, Capocelli K, Lovell M, and Furuta GT. Eosinophilic esophagitis: the newest esophageal inflammatory disease. Nat Rev Gastroenterol Hepatol. 2009 May;6(5):267-78. DOI:10.1038/nrgastro.2009.45 | PubMed ID:19404267 | HubMed [Paper]
  23. Rothenberg ME. Biology and treatment of eosinophilic esophagitis. Gastroenterology. 2009 Oct;137(4):1238-49. DOI:10.1053/j.gastro.2009.07.007 | PubMed ID:19596009 | HubMed [Paper]
  24. Müller S, Pühl S, Vieth M, and Stolte M. Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitis. Endoscopy. 2007 Apr;39(4):339-44. DOI:10.1055/s-2007-966216 | PubMed ID:17427070 | HubMed [Paper]
  25. Straumann A, Bauer M, Fischer B, Blaser K, and Simon HU. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol. 2001 Dec;108(6):954-61. DOI:10.1067/mai.2001.119917 | PubMed ID:11742273 | HubMed [Paper]
  26. Aceves SS, Newbury RO, Dohil R, Schwimmer J, and Bastian JF. Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder. J Clin Gastroenterol. 2007 Mar;41(3):252-6. DOI:10.1097/01.mcg.0000212639.52359.f1 | PubMed ID:17426462 | HubMed [Paper]
  27. Spergel JM. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol. 2007 Jun;7(3):274-8. DOI:10.1097/ACI.0b013e32813aee4a | PubMed ID:17489048 | HubMed [Paper]
  28. Penfield JD, Lang DM, Goldblum JR, Lopez R, and Falk GW. The role of allergy evaluation in adults with eosinophilic esophagitis. J Clin Gastroenterol. 2010 Jan;44(1):22-7. DOI:10.1097/MCG.0b013e3181a1bee5 | PubMed ID:19564792 | HubMed [Paper]
  29. Spergel JM, Brown-Whitehorn TF, Beausoleil JL, Franciosi J, Shuker M, Verma R, and Liacouras CA. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):30-6. DOI:10.1097/MPG.0b013e3181788282 | PubMed ID:19172120 | HubMed [Paper]
  30. Pentiuk S, Putnam PE, Collins MH, and Rothenberg ME. Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):152-60. DOI:10.1097/MPG.0b013e31817f0197 | PubMed ID:19179876 | HubMed [Paper]
  31. Leslie C, Mews C, Charles A, and Ravikumara M. Celiac disease and eosinophilic esophagitis: a true association. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):397-9. DOI:10.1097/MPG.0b013e3181a70af4 | PubMed ID:19841598 | HubMed [Paper]
  32. Moawad FJ, Veerappan GR, Lake JM, Maydonovitch CL, Haymore BR, Kosisky SE, and Wong RK. Correlation between eosinophilic oesophagitis and aeroallergens. Aliment Pharmacol Ther. 2010 Feb 15;31(4):509-15. DOI:10.1111/j.1365-2036.2009.04199.x | PubMed ID:19925501 | HubMed [Paper]
  33. Stone KD and Prussin C. Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases. Clin Exp Allergy. 2008 Dec;38(12):1858-65. DOI:10.1111/j.1365-2222.2008.03122.x | PubMed ID:19037962 | HubMed [Paper]
  34. Simon D, Straumann A, Wenk A, Spichtin H, Simon HU, and Braathen LR. Eosinophilic esophagitis in adults--no clinical relevance of wheat and rye sensitizations. Allergy. 2006 Dec;61(12):1480-3. DOI:10.1111/j.1398-9995.2006.01224.x | PubMed ID:17073881 | HubMed [Paper]
  35. Sugnanam KK, Collins JT, Smith PK, Connor F, Lewindon P, Cleghorn G, and Withers G. Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy. 2007 Nov;62(11):1257-60. DOI:10.1111/j.1398-9995.2007.01454.x | PubMed ID:17711545 | HubMed [Paper]
  36. Aceves SS, Newbury RO, Chen D, Mueller J, Dohil R, Hoffman H, Bastian JF, and Broide DH. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy. 2010 Jan;65(1):109-16. DOI:10.1111/j.1398-9995.2009.02142.x | PubMed ID:19796194 | HubMed [Paper]
  37. Lucendo AJ, De Rezende L, Comas C, Caballero T, and Bellón T. Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Am J Gastroenterol. 2008 Sep;103(9):2184-93. DOI:10.1111/j.1572-0241.2008.01937.x | PubMed ID:18844613 | HubMed [Paper]
  38. Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, and Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20. DOI:10.1136/gut.2009.178020 | PubMed ID:19528036 | HubMed [Paper]
  39. Straumann A, Conus S, Grzonka P, Kita H, Kephart G, Bussmann C, Beglinger C, Smith DA, Patel J, Byrne M, and Simon HU. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut. 2010 Jan;59(1):21-30. DOI:10.1136/gut.2009.178558 | PubMed ID:19828470 | HubMed [Paper]
  40. Flood EM, Beusterien KM, Amonkar MM, Jurgensen CH, Dewit OE, Kahl LP, and Matza LS. Patient and caregiver perspective on pediatric eosinophilic esophagitis and newly developed symptom questionnaires*. Curr Med Res Opin. 2008 Dec;24(12):3369-81. DOI:10.1185/03007990802536900 | PubMed ID:19032119 | HubMed [Paper]
  41. Quiroga J, Prim JM, Moldes M, and Ledo R. Spontaneous circumferential esophageal dissection in a young man with eosinophilic esophagitis. Interact Cardiovasc Thorac Surg. 2009 Dec;9(6):1040-2. DOI:10.1510/icvts.2009.208975 | PubMed ID:19752151 | HubMed [Paper]
  42. Spergel JM, Beausoleil JL, Mascarenhas M, and Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002 Feb;109(2):363-8. PubMed ID:11842310 | HubMed [Paper]
  43. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, and Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003 Dec;125(6):1660-9. PubMed ID:14724818 | HubMed [Paper]
  44. Spergel JM and Brown-Whitehorn T. The use of patch testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2005 Jan;5(1):86-90. PubMed ID:15659270 | HubMed [Paper]
  45. Straumann A, Kristl J, Conus S, Vassina E, Spichtin HP, Beglinger C, and Simon HU. Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract. Inflamm Bowel Dis. 2005 Aug;11(8):720-6. PubMed ID:16043986 | HubMed [Paper]
  46. Putnam PE and Rothenberg ME. Eosinophilic esophagitis: concepts, controversies, and evidence. Curr Gastroenterol Rep. 2009 Jun;11(3):220-5. PubMed ID:19463222 | HubMed [Paper]
  47. Domínguez-Ortega J, Pérez-Bedmar J, Rodríguez-Jiménez B, Butrón M, Kindelan C, and Ledesma A. Eosinophilic esophagitis due to profilin allergy. J Investig Allergol Clin Immunol. 2009;19(4):338-9. PubMed ID:19639743 | HubMed [Paper]
  48. Landres RT, Kuster GG, and Strum WB. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 1978 Jun;74(6):1298-1301. PubMed ID:648822 | HubMed [Paper]
All Medline abstracts: PubMed | HubMed

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