Quint Lab:Research: Difference between revisions
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<h3><font style="color:#F8B603;">let's play</font></h3> | |||
"real science has the potential to not only amaze, but also transform the way one thinks of the world and oneself. this is because the process of science is little different from the deeply resonant, natural processes of play. play enables humans (and other mammals) to discover (and create) relationships and patterns. when one adds rules to play, a game is created. this is science: the process of playing with rules that enables one to reveal previously unseen patterns of relationships that extend our collective understanding of nature." - [http://rsbl.royalsocietypublishing.org/content/7/2/168.long Blackawton et al., 2011, Biology letters] | |||
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'''HOW''' do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? <br> | '''HOW''' do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? <br> | ||
major players in the conversion of such stimuli into cellular responses are hormones acting as signaling molecules. | major players in the conversion of such stimuli into cellular responses are hormones acting as signaling molecules. | ||
our lab is primarily interested in understanding the genetics and molecular biology of [http://en.wikipedia.org/wiki/Auxin auxin] and other [http://en.wikipedia.org/wiki/Plant_hormone plant hormone] responses in the tiny weed [http://en.wikipedia.org/wiki/Arabidopsis_thaliana arabidopsis thaliana] and related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae]. phytohormones are one of the classic fields in [http://en.wikipedia.org/wiki/Plant_physiology plant physiology] and the past has shown that understanding hormone action in plants bears great potential for agricultural and horticultural applications. by contributing to the current state of knowledge of hormone biology we hope to participate in the advancement of [http://en.wikipedia.org/wiki/Crop_science crop science]. | our lab is primarily interested in understanding the genetics and molecular biology of [http://en.wikipedia.org/wiki/Auxin auxin] and other [http://en.wikipedia.org/wiki/Plant_hormone plant hormone] responses in the tiny weed [http://en.wikipedia.org/wiki/Arabidopsis_thaliana arabidopsis thaliana] and related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae]. phytohormones are one of the classic fields in [http://en.wikipedia.org/wiki/Plant_physiology plant physiology] and the past has shown that understanding hormone action in plants bears great potential for agricultural and horticultural applications. by contributing to the current state of knowledge of hormone biology we hope to participate in the advancement of [http://en.wikipedia.org/wiki/Crop_science crop science]. | ||
Secondly, we are fascinated by the mechanisms of [http://en.wikipedia.org/wiki/Molecular_evolution molecular evolution] and how they shape plant life. Learning about the evolutionary history of signaling pathways may help to further our understanding of important developmental processes regulated by these signaling cascades. | |||
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we apply mostly [http://en.wikipedia.org/wiki/Genomics genomics] approaches, such as: | we apply mostly [http://en.wikipedia.org/wiki/Genomics genomics] approaches, such as: | ||
*forward [http://en.wikipedia.org/wiki/Genetic_screen genetic screens] and [http://en.wikipedia.org/wiki/Reverse_genetics reverse genetics] | *forward [http://en.wikipedia.org/wiki/Genetic_screen genetic screens] and [http://en.wikipedia.org/wiki/Reverse_genetics reverse genetics] | ||
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from an evolutionary perspective it will be important to learn about the differences in auxin responses on the physiological and the transcriptional level between species. Comparison of inter-species with intra-species variation may shed new light on the evolutionary development of the auxin response pathway(s). We are using closely related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae] species such as thlaspi arvense in this picture for this type of analysis which - in addition to the evolutionary perspective - is most interesting for possible future knowledge transfer to agronomically important species from that family. | from an evolutionary perspective it will be important to learn about the differences in auxin responses on the physiological and the transcriptional level between species. Comparison of inter-species with intra-species variation may shed new light on the evolutionary development of the auxin response pathway(s). We are using closely related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae] species such as thlaspi arvense in this picture for this type of analysis which - in addition to the evolutionary perspective - is most interesting for possible future knowledge transfer to agronomically important species from that family. | ||
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=== | ===evo-devo=== | ||
[[Image:Hourglass_mosaic.jpg|100px|right]] | |||
for one, we are interested in the evolutionary history of gene families that are involved in important signaling cascades, such as the ubiquitin-proteasome system (see schumann et al. [http://www.ncbi.nlm.nih.gov/pubmed/21119043 ''plant physiology 2011'']). furthermore, we are developing ways to utilize whole genome transcriptional information for evolutionary approaches in close collaboration with the lab of [http://www.informatik.uni-halle.de/arbeitsgruppen/bioinformatik/mitarbeiterinnen/grosse/?lang=en ivo grosse]. by applying phylotranscriptomics – the combination of [http://en.wikipedia.org/wiki/Phylogenetics phylogenetics] and [http://en.wikipedia.org/wiki/Transcriptomics transcriptomics] – to developmental series such as embryogenesis, we are able to trace the evolutionary path across a complete developmental process. | |||
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Revision as of 00:34, 6 December 2012
let's play"real science has the potential to not only amaze, but also transform the way one thinks of the world and oneself. this is because the process of science is little different from the deeply resonant, natural processes of play. play enables humans (and other mammals) to discover (and create) relationships and patterns. when one adds rules to play, a game is created. this is science: the process of playing with rules that enables one to reveal previously unseen patterns of relationships that extend our collective understanding of nature." - Blackawton et al., 2011, Biology letters |
broad research scopeHOW do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? Secondly, we are fascinated by the mechanisms of molecular evolution and how they shape plant life. Learning about the evolutionary history of signaling pathways may help to further our understanding of important developmental processes regulated by these signaling cascades.
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natural variation and quantitative genetics of hormone responsesquantitative genetics
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evo-devofor one, we are interested in the evolutionary history of gene families that are involved in important signaling cascades, such as the ubiquitin-proteasome system (see schumann et al. plant physiology 2011). furthermore, we are developing ways to utilize whole genome transcriptional information for evolutionary approaches in close collaboration with the lab of ivo grosse. by applying phylotranscriptomics – the combination of phylogenetics and transcriptomics – to developmental series such as embryogenesis, we are able to trace the evolutionary path across a complete developmental process. |