Hoatlin: Fundamentals: Difference between revisions
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*What is the difference between "alternative RNA Processing" and "alternative protein processing"? | *What is the difference between "alternative RNA Processing" and "alternative protein processing"? | ||
;Answer | ;Answer | ||
*Alternative RNA processing is exhibited in the example of | *Alternative RNA processing is exhibited in the example of calcitonin and calcitonin gene related peptide. The same transcript is spliced in different ways to achieve different mRNAs and thus alternative proteins. | ||
calcitonin and calcitonin gene related peptide. The same transcript is | |||
spliced in different ways to achieve different mRNAs and thus alternative proteins. | |||
*Alternative protein processing can refer to a number of things. Rather than confuse the | *Alternative protein processing can refer to a number of things. Rather than confuse the issue with examples, Let me know where the statement was in the notes so I can clarify. | ||
issue with examples, Let me know where the statement was in the notes so I can clarify. | |||
;Question | ;Question | ||
*Can you shed some light on what is important about SINEs and LINEs, | *Can you shed some light on what is important about SINEs and LINEs, other than being transposons? | ||
other than being transposons? | |||
;Answer | ;Answer | ||
*LINEs and SINEs are important to know about because (1) they | *LINEs and SINEs are important to know about because (1) they provide knowledge about a large part of the human genome (2) the role of SINEs and LINEs in genome evolution (e.g., via recombination) and (3) it is likely that a clearer picture of the activities of LINEs and SINEs in genomic stability and clinically-important influences will continue to emerge (see abstract for a recent review: http://www.ncbi.nlm.nih.gov/pubmed/20307669). | ||
provide knowledge about a large part of the human genome (2) the role of | |||
SINEs and LINEs in genome evolution (e.g., via recombination) and (3) it is | |||
likely that a clearer picture of the activities of LINEs and SINEs in genomic | |||
stability and clinically-important influences will continue to emerge (see | |||
abstract for a recent review: http://www.ncbi.nlm.nih.gov/pubmed/20307669). | |||
;Question | ;Question |
Revision as of 20:18, 22 January 2012
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That's how PARP1 inhibitors are relatively selective in killing the HR deficient tumor cell but not the wild-type cell (which is competent for HR)
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