Harvard:Biophysics 101/2007/Notebook:HRH/2007-3-13: Difference between revisions
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(New page: Link to assignment: http://openwetware.org/wiki/Harvard:Biophysics_101/2007/03/13 ===Task 1=== After running the NCBI Blast, I received the following results: <pre> NT_030059.12 Homo s...) |
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Revision as of 13:14, 13 March 2007
Link to assignment:
http://openwetware.org/wiki/Harvard:Biophysics_101/2007/03/13
Task 1
After running the NCBI Blast, I received the following results:
NT_030059.12 Homo sapiens chromosome 10 genomic contig, reference assembly NW_924884.1 Homo sapiens chromosome 10 genomic contig, alternate assembly (based on Celera assembly)
Additionally, the flanking proteins are:
- 3895 bp at 5' side: hypothetical protein
- 425 bp at 3' side: HtrA serine peptidase 1
There is a point mutation at bp 201 (A-T -> A-G).
The reading frame containing the ATG start codon has the mutation changing the amino acid from a CAG to CGG (Glutamine to Arginine). Glutamine is polar and neutral, and Arginine is also polar and strongly basic (they are both hydrophilic).
Laymen's terms: the mutation probably will not do any harm (i.e. don't worry).
