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Key Questions

  1. What proportion of newly synthesized proteins fail to fold, and why?
  2. How do cells tell when a protein is misfolded, rather than simply in the process of folding? Do cells actually make such distinctions?
  3. What is the cost of producing a protein that misfolds, compared to the cost if that protein folds properly?
  4. Why are misfolded proteins costly?
  5. How does inaccuracy in the translational apparatus (ribosomes, aa-tRNA synthetases, etc.) shape the evolution of coding sequences and proteins?