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| *When and where we meet | | *When and where we meet |
| :MacHall 2136 | | :MacHall 2136 |
| :Thursdays noon-1 PM | | :Tuesdays noon-1 PM |
| :Lunch provided by KCI | | :Lunch provided by KCI |
| *Organizer contact information: | | *Organizer contact information: |
| : Rosie Sears-searsr@ohsu.edu | | : Mushui Dai-daim@ohsu.edu |
| : Charlie Lopez- lopezc@ohsu.edu | | : David Qian-qianzh@ohsu.edu |
| | : Anupriya Agarwal-agarwala@ohsu.edu |
|
| |
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| ==Member Labs and Affiliations== | | ==Member Labs and Affiliations== |
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| |
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| |-- | | |-- |
| |9/27/2012 | | |09/26/2017 |
| |Rosalie Sears | | | |
| |Organization | | |Organization |
| | | | | |
| |-- | | |-- |
| |10/4/2012 | | |10/3/2017 |
| |Brittany Allen-Petersen | | |David Qian |
| |Tumourmicro-environment elicits innate resistance to RAF inhibitors through HGF secretion | | | |
| |[http://www.nature.com/nature/journal/v487/n7408/full/nature11183.html Straussman et al] | | | |
| |-- | | |-- |
| |10/11/2012 | | |10/10/2017 |
| |Ellen Langer | | |Sudarshan Iyer |
| |A restricted cell population propagates glioblastoma growth after chemotherapy | | | |
| |[http://openwetware.org/images/3/3a/Chen_Nature_2012.pdf Chen, et al] Additional vivo detection papers [http://www.ncbi.nlm.nih.gov/pubmed/22854777 1] [http://www.ncbi.nlm.nih.gov/pubmed/22855427 2] | | | |
| |-- | | |-- |
| |10/18/2012 | | |10/17/2017 |
| |Yulong Su | | |Lilli Klug |
| |Transcriptional Amplification in Tumor Cells with Elevated c-Myc; | | | |
| c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
| | | |
| |[http://www.sciencedirect.com/science/article/pii/S0092867412010574 Lin 2012] | |
| [http://www.sciencedirect.com/science/article/pii/S0092867412011014 Nie 2012]
| |
| |-- | | |-- |
| |10/25/2012 | | |10/24/2017 |
| |****CANCELLED**** Dr. Charles Lopez | | |Marilynn Chow |
| | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer | | | |
| |[http://openwetware.org/images/a/a5/Nature11156.pdf Misale at. al] [http://openwetware.org/images/3/33/Nature11156-s1.pdf supp. info] | | | |
| |-- | | |-- |
| |11/1/2012 | | |10/31/2017 |
| |Asia Mitchell | | |No JC |
| |Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks | | | |
| |[http://www.sciencedirect.com/science/article/pii/S0092867412004199] | | | |
| |-- | | |-- |
| |11/8/2012 | | |11/7/201 |
| |Yuhan Wang | | |Ben Doron |
| |"Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Melanoma" | | | |
| |[http://openwetware.org/images/4/4e/Journal_Club_paper-5hmc.pdf] | | | |
| |-- | | |-- |
| |11/15/2012 | | |11/14/20167 |
| |Tyler Risom | | |Hsin-Yun Lin |
| |Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer | | | |
| | [http://openwetware.org/images/8/85/PI3K_and_Parp_1.full.pdf Ashish et. al.] [http://openwetware.org/images/8/82/PI3K_and_Parp_2.full.pdf Yasir et al] | | | |
| |-- | | |-- |
| |11/22/2012 | | |11/21/2017 |
| |xxxxxxxxxx | | |Chelsea Jenkins |
| |THANKSGIVING, NO JOURNAL CLUB | | | |
| |xxxxxxxxxx | | | |
| |-- | | |-- |
| |11/29/2012 | | |11/28/2017 |
| |Dr. Swarnali Acharyya, a CDB/Knight faculty candidate seminar | | |Xiao-Xin Sun |
| | | | | |
| | | | | |
| |-- | | |-- |
| |12/6/2012 | | |12/05/2017 |
| |Marilynn Chow | | |Jason Kent |
| |Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression | | | |
| |[http://openwetware.org/images/1/1d/2012_Oncogene_Pagliuca_et_al.pdf Pagliuca et al] [http://openwetware.org/images/3/3f/2012_Oncogene_Pagliuca_et_al_Supp.pdf supplement] | | | |
| |-- | | |-- |
| |1/10/2013 | | |12/12/2017 |
| |Lilli Welch | | |Fatma Eryildiz |
| | | | | |
| | | | | |
| |-- | | |-- |
| |1/17/2013 | | |12/19/2017 |
| |Spencer Watson | | |David Edwards |
| |Mitochondrial dynamics regulates migration and invasion of breast cancer cells | | | |
| |[http://openwetware.org/images/4/4b/Onc2012494a.pdf] | | | |
| |-- | | |-- |
| |1/24/2013 | | |12/26/2017 |
| |Ping Wang | | |NO JC |
| |Oncogenic Kras-Induced GM-CSF Projection Promotes the Development of Pancreatic Neoplasia | | | |
| |[http://www.ncbi.nlm.nih.gov/pubmed/22698407] [http://www.ncbi.nlm.nih.gov/pubmed/22698406] | | | |
| |-- | | |-- |
| |1/31/2013 | | |1/2/2018 |
| |Aaron Wortham | | | |
| |Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration | | |Organization |
| |[http://openwetware.org/images/5/51/Luga_V_et_al_Cell_2012.pdf Luga V et al Cell 151, 1542-1556 (2012)] | | | |
| |-- | | |-- |
| |2/7/2013 | | |1/9/2018 |
| |Jeff Wu | | |Ben Doron |
| |MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrinsubunits | | | |
| | [http://www.nature.com/ncb/journal/v14/n6/pdf/ncb2491.pdf] | | | |
| |-- | | |-- |
| |2/14/2013 | | |1/16/2018 |
| |Tiffany Devine | | |Kevin Watanabe-Smith |
| |The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites | | | |
| |[http://openwetware.org/images/3/3c/Gao_Cell_2012_BMP_inhibitor_coco_reactivates_BCC_at_lung_met_sites.pdf] | | | |
| |-- | | |-- |
| |2/21/2013 | | |1/23/2018 |
| |Ellie Juarez | | |Xiaoming Ouyang |
| |Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo Molecular Cancer Therapeutics | | | |
| |[http://openwetware.org/images/b/bd/Gene_Therapy_JC_and_class.pdf] | | | |
| |-- | | |-- |
| |2/28/2013 | | |1/30/2018 |
| |Tim Butler | | |Hsin-Yun Lin |
| |tumor heterogeneity, focusing mostly on a recent science paper (Kreso 2013) which shows serially passages clones responding differently to chemotherapy | | | |
| |[http://openwetware.org/images/0/09/Science-2013-Kreso-543-8.pdf Kreso 2013][http://openwetware.org/images/2/25/Gerlinger_2012%2C_Intratumor_Heterogeneity_multiregion_sequencing.pdf Gerlinger 2012] | | | |
| |-- | | |-- |
| |3/7/2013 | | |2/06/2018 |
| |Toni West | | |Fatma Eryildiz |
| |Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties | | | |
| |[http://openwetware.org/images/c/c3/Schwitalla_S_et_al_Cell_152%2C_25-38_%282013%29.pdf Schwitalla S et al Cell 152, 25-38 (2013)] | | | |
| |-- | | |-- |
| |3/14/2013 | | |2/13/2018 |
| |Jared Fischer | | |Hannah Sanford-Crane |
| |Intestinal label-retaining cells are secretory precursors expressing Lgr5 | | | |
| |[http://openwetware.org/images/0/09/Nature11965%281%29.pdf] | | | |
| |-- | | |-- |
| |3/21/2013 | | |2/20/2018 |
| |Mushui Dai | | |Yingxiao Chen |
| |Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence. | | | |
| |[http://openwetware.org/images/5/57/2013_SRSF1_L5_p53_MC.pdf] | | | |
| |-- | | |-- |
| |4/4/2013 | | |2/27/2018 |
| |Nathalie Javidi-Sharifi | | |David Edwards |
| |Tumor Stem Cells Generate Vasculature | | | |
| |[http://openwetware.org/images/2/25/Gsc_vasculature_hutchinson_comment_nature_2011.pdf] [http://openwetware.org/images/1/17/Gsc_pericytes_cheng_cell_2013_incl_supp.pdf] | | | |
| |-- | | |-- |
| |4/11/2013 | | |3/06/2018 |
| |Amy Farrell | | |Jason Kent |
| |Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer | | | |
| |[http://www.sciencedirect.com/science/article/pii/S1535610813000433 Stefan Eser, et al] | | | |
| | |-- |
| | |3/13/2018 |
| | |Xiao-Xin Sun |
| | | |
| | | |
| |-- | | |-- |
| |4/18/2013 | | |3/20/2018 |
| |Trevor Levin | | |Canceled |
| |DNA damage foci formation around double strand breaks and regulation of NHEJ and HR repair mechanisms | | | |
| |[http://openwetware.org/images/5/59/Zimmermann2013_53BP1_Rif1_DSBRepair.pdf Zimmerman][http://openwetware.org/images/b/ba/Virgilio2013_Rif1_DNA_Breaks_IG_Switching.pdf Virgilio][http://openwetware.org/images/7/72/Kukas2013_Rif1_Perspective.pdf Kukas] | | | |
| |-- | | |-- |
| |4/25/2013 | | |3/27/2018 |
| |Kevin Watanabe-Smith | | |Canceled, spring break |
| |"Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models" | | | |
| |[http://openwetware.org/images/5/56/Corcoran_2013_Synthetic_Lethality_in_KRAS_mutant_cancer.pdf] [http://openwetware.org/images/6/68/Supplemental_-_Corcoran_2013.pdf] | | | |
| | |-- |
| | |4/3/2018 |
| | | |
| | |Organization |
| | | |
| | |-- |
| | |4/10/2018 |
| | |Jungsun Kim |
| | | |
| | | |
| | |-- |
| | |4/17/2018 |
| | |Hannah Sanford-Crane |
| | | |
| | | |
| |-- | | |-- |
| |5/2/2013 | | |4/24/2018 |
| |Stacey Lin | | |David Qian |
| |Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion | | | |
| |[http://openwetware.org/images/a/ac/Li_and_Hanahan.pdf] | | | |
| |-- | | |-- |
| |5/9/2013 | | |5/1/2018 |
| |Juan Liang | | |Canceled---research week |
| |Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
| |
| | | | | |
| |-- | | |-- |
| |5/16/201 | | |5/8/2018 |
| |Xiaoxin Sun | | |Anupriya Agarwal |
| | | | | |
| | | | | |
| |-- | | |-- |
| |5/23/2013 | | |5/15/2018 |
| |Dr. Charles Lopez | | |Yingxiao Chen |
| | | | | |
| | | | | |
| |-- | | |-- |
| |5/30/2013 | | |5/22/2018 |
| |Mahnaz Janghorban | | |Kevin Watanabe-Smith |
| | | | | |
| | | | | |
| |-- | | |-- |
| |6/6/2013 | | |5/29/2018 |
| |Marcus Calkins | | |Hsin-Yun Lin |
| | | |
| | | | | |
| | |-- |
| | |6/05/2018 |
| | |Rick Rollins |
| | | | | |
| |} | | |} |
| </div> | | </div> |
Objectives of the OHSU Cancer Biology Journal Club
Cross-departmental journal club composed of students, postdocs, fellows and clinical and basic science faculty with shared interest in basic principles, emerging discoveries, and new therapeutic approaches in Cancer Biology. The goals of the meetings are to:
- Critically evaluate new cutting edge literature on mechanisms underlying the development and maintenance of cancer to inform the development of new therapeutics. Papers should be paradigm shifting and set a backdrop for discussion into therapeutics facilitated by the clinical attendees.
- Provide students, postdocs and fellows with training and interactions with faculty interested in Cancer Biology and emerging therapeutics
Want to join us? All are invited!
- go to the following web site:
- http://mailman.ohsu.edu/cgi-bin/mailman/listinfo/oncobio
- follow instructions for subscribing
- Send an e-mail to 'oncobioATohsu.edu' with your paper attached
- MacHall 2136
- Tuesdays noon-1 PM
- Lunch provided by KCI
- Organizer contact information:
- Mushui Dai-daim@ohsu.edu
- David Qian-qianzh@ohsu.edu
- Anupriya Agarwal-agarwala@ohsu.edu
Member Labs and Affiliations
Lopez Lab Hem Onc
Sears Lab
Hoatlin Lab
Thayer Lab
Wong Lab
Lloyd Lab CROET
McCullough Lab CROET
Schedule
| Date
|
Presenters
|
Topic
|
Links & Comments
|
| 09/26/2017
|
|
Organization
|
|
| 10/3/2017
|
David Qian
|
|
|
| 10/10/2017
|
Sudarshan Iyer
|
|
|
| 10/17/2017
|
Lilli Klug
|
|
|
| 10/24/2017
|
Marilynn Chow
|
|
|
| 10/31/2017
|
No JC
|
|
|
| 11/7/201
|
Ben Doron
|
|
|
| 11/14/20167
|
Hsin-Yun Lin
|
|
|
| 11/21/2017
|
Chelsea Jenkins
|
|
|
| 11/28/2017
|
Xiao-Xin Sun
|
|
|
| 12/05/2017
|
Jason Kent
|
|
|
| 12/12/2017
|
Fatma Eryildiz
|
|
|
| 12/19/2017
|
David Edwards
|
|
|
| 12/26/2017
|
NO JC
|
|
|
| 1/2/2018
|
|
Organization
|
|
| 1/9/2018
|
Ben Doron
|
|
|
| 1/16/2018
|
Kevin Watanabe-Smith
|
|
|
| 1/23/2018
|
Xiaoming Ouyang
|
|
|
| 1/30/2018
|
Hsin-Yun Lin
|
|
|
| 2/06/2018
|
Fatma Eryildiz
|
|
|
| 2/13/2018
|
Hannah Sanford-Crane
|
|
|
| 2/20/2018
|
Yingxiao Chen
|
|
|
| 2/27/2018
|
David Edwards
|
|
|
| 3/06/2018
|
Jason Kent
|
|
|
| 3/13/2018
|
Xiao-Xin Sun
|
|
|
| 3/20/2018
|
Canceled
|
|
|
| 3/27/2018
|
Canceled, spring break
|
|
|
| 4/3/2018
|
|
Organization
|
|
| 4/10/2018
|
Jungsun Kim
|
|
|
| 4/17/2018
|
Hannah Sanford-Crane
|
|
|
| 4/24/2018
|
David Qian
|
|
|
| 5/1/2018
|
Canceled---research week
|
|
| 5/8/2018
|
Anupriya Agarwal
|
|
|
| 5/15/2018
|
Yingxiao Chen
|
|
|
| 5/22/2018
|
Kevin Watanabe-Smith
|
|
|
| 5/29/2018
|
Hsin-Yun Lin
|
|
|
| 6/05/2018
|
Rick Rollins
|
|