20.949/F10:Schedule

Date	Topic	Assignment
September 9	Overview of Synthetic Biology
September 14	Biophysical Models of Basic Biological Processes I
September 16	Biophysical Models of Basic Biological Processes II
September 21	Noise propagation and regulatory feedback
September 23	Computational modeling of genetic circuits (ODE, stochastic, Lambda)
September 28	Dynamics of Biological Circuits -- Feed-forward motifs
September 30	Dynamics of Biological Circuits -- Toggle switches and bistability
September 30	Dynamics of Biological Circuits -- Oscillators
October 5	Dynamics of Biological Circuits -- Bifurcation analysis / phase space
October 7	Cell-cell communication I
October 12	Cell-cell communication II
October 14	RNA regulation (bacterial / microbial)
October 19	RNA regulation (Eukarytoic)
October 21	Protein tagging: secretion / localization / degradation
October 26	Protein engineering (modular design of proteins) to explore functional
October 28	Protein-protein interaction networks
November 2	Metabolic engineering
November 4	Interfacing to other cell functions
November 9	Principles of design -- from parts to modules to systems I
November 11	Principles of design -- from parts to modules to systems II
November 16	Principles of design -- from parts to modules to systems III
November 18	Principles of design -- from parts to modules to systems IV
November 23	Directed evolution (parts & circuits)
November 30	History of DNA manipulation
December 2	Advanced DNA design & cloning
December 7	Synthetic biology applications
December 9	Synthetic Life / Perspectives & challenges
December X-Y	Term project presentations