- Target a pathway other than SOS
- Use a different bacteriophage
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Resources needed to complete the work
Importance of Project (Application)
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Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Lu, Timothy and Collins, James. PNAS. 2008.
This paper proposes a method to reduce bacterial antibiotic resistance. The scientists use bacteriophage to target the SOS gene network (that are non-essential to bacterial survival but tend to be upregulated in order to cause bacterial resistance) but not the networks targeted by the antibiotics. With a combination of both bacterial killing and bacteriophage that enhances the antibiotics, these scientists hope to reduce bacterial resistance and increase bacterial death.