User:Wayne G. Shreffler

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Contact Info

Wayne G. Shreffler
Wayne G. Shreffler

Wayne G. Shreffler, MD, PhD

MassGeneral Hospital for Children &

MGH, Center for Immunology and Inflammatory Diseases

Bldg. 149-13th St. Rm. 8312

Charlestown MA 02129

Links:

Education

  • 1998, MD, New York University
  • 1997, PhD, New York University
  • 1996, MS, New York University
  • 1991, BS, University of Washington

Research interests

  1. Mechanisms of Allergenicity
  2. Immune Tolerance and Food Allergy
  3. Mechanisms of Immediate Hypersensitivity and its Regulation

Publications

PubMed Link

Selected Research Articles

  1. Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol 2009 Apr; 123(4) 789-94.e20. doi:10.1016/j.jaci.2008.12.1128 pmid:19348919. PubMed HubMed PubGet [Paper1]
  2. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009 Jan; 123(1) 43-52.e7. doi:10.1016/j.jaci.2008.09.051 pmid:19130927. PubMed HubMed PubGet [Paper2]
  3. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol 2008 Mar; 121(3) 737-743.e10. doi:10.1016/j.jaci.2007.11.039 pmid:18234310. PubMed HubMed PubGet [Paper3]
  4. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol 2006 Sep 15; 177(6) 3677-85. pmid:16951327. PubMed HubMed PubGet [Paper4]
  5. Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol 2005 Oct; 116(4) 893-9. doi:10.1016/j.jaci.2005.06.033 pmid:16210066. PubMed HubMed PubGet [Paper5]
  6. Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 2004 Apr; 113(4) 776-82. doi:10.1016/j.jaci.2003.12.588 pmid:15100687. PubMed HubMed PubGet [Paper6]
All Medline abstracts: PubMed HubMed

Selected Review Articles

  1. Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol 2009; 524 259-72. doi:10.1007/978-1-59745-450-6_19 pmid:19377951. PubMed HubMed PubGet [Paper1]
  2. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol 2009 Feb; 123(2) 352-3. doi:10.1016/j.jaci.2008.12.1119 pmid:19203659. PubMed HubMed PubGet [Paper2]
  3. Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol 2008 Nov; 101(5) 544-9. pmid:19055210. PubMed HubMed PubGet [Paper3]
  4. Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol 2008 Jun; 121(6) 1311-20; quiz 1321-2. doi:10.1016/j.jaci.2008.04.023 pmid:18539190. PubMed HubMed PubGet [Paper4]
  5. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol 2006 Jun; 6(3) 226-33. doi:10.1097/01.all.0000225165.83144.2f pmid:16670519. PubMed HubMed PubGet [Paper5]
All Medline abstracts: PubMed HubMed

Useful links

Shreffler

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