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Contact Info

Roger L. Chang
Roger L. Chang
  • Roger L. Chang
  • Postdoc, lab of Pamela Silver
  • Systems Biology Dept, Harvard Medical School
  • 200 Longwood Avenue WAB 561
  • Boston, MA 02115
  • Email me through OpenWetWare


  • 2012, PhD in Bioinformatics and Systems Biology, University of California San Diego (lab of Bernhard Ø. Palsson)
  • 2005, BA in Molecular and Cell Biology, University of California Berkeley (lab of Nipam Patel)

Research interests

  1. Synthetic RNA Structure Engineering
  2. Radioresistance of Deinococcus radiodurans
  3. Metabolic Systems Modeling
  4. Structural Systems Biology


  1. Chang RL, Xie L, Bourne PE, and Palsson BO. . pmid:24112686. PubMed HubMed [BMC_Syst_Biol_2013_Oct_10_7-102_Antibacterial_mechanisms_identified_through_structural_systems_pharmacology]
  2. O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, and Palsson BØ. . pmid:24084808. PubMed HubMed [Mol_Syst_Biol_2013_Oct_1_9_693_Genome-scale_models_of_metabolism_and_gene_expression_extend_and_refine_growth_phenotype_prediction]
  3. Chang RL, Andrews K, Kim D, Li Z, Godzik A, and Palsson BO. . pmid:23744946. PubMed HubMed [Science_2013_Jun_7_340_1220_1223_Structural_systems_biology_evaluation_of_metabolic_thermotolerance_in_Escherichia_coli]
  4. Nam H, Lewis NE, Lerman JA, Lee DH, Chang RL, Kim D, and Palsson BO. . pmid:22936779. PubMed HubMed [Science_2012_Aug_31_337_1101_1104_Network_context_and_selection_in_the_evolution_to_enzyme_specificity]
  5. Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ, Salehi-Ashtiani K, and Papin JA. . pmid:21811229. PubMed HubMed [Mol_Syst_Biol_2011_Aug_2_7518_Metabolic_network_reconstruction_of_Chlamydomonas_offers_insight_into_light-driven_algal_metabolism]
  6. Chang RL, Xie L, Xie L, Bourne PE, and Palsson BØ. . pmid:20957118. PubMed HubMed [PLoS_Comput_Biol_2010_Sep_23_6_e1000938_Drug_off-target_effects_predicted_using_structural_analysis_in_the_context_of_a_metabolic_network_model]
  7. Chang RL, Luo F, Johnson S, and Scheuermann RH. . pmid:20223734. PubMed HubMed [Int_J_Bioinform_Res_Appl_2010_6_101_19_Deterministic_graph-theoretic_algorithm_for_detecting_modules_in_biological_interaction_networks]
  8. Manichaikul A, Ghamsari L, Hom EF, Lin C, Murray RR, Chang RL, Balaji S, Hao T, Shen Y, Chavali AK, Thiele I, Yang X, Fan C, Mello E, Hill DE, Vidal M, Salehi-Ashtiani K, and Papin JA. . pmid:19597503. PubMed HubMed [Nat_Methods_2009_Aug_6_589_92_Metabolic_network_analysis_integrated_with_transcript_verification_for_sequenced_genomes]
  9. Squires B, Macken C, Garcia-Sastre A, Godbole S, Noronha J, Hunt V, Chang R, Larsen CN, Klem E, Biersack K, and Scheuermann RH. . pmid:17965094. PubMed HubMed [Nucleic_Acids_Res_2008_Jan_36_Database_issue_D497_503_BioHealthBase_informatics_support_in_the_elucidation_of_influenza_virus_host_pathogen_interactions_and_virulence]
  10. Luo F, Yang Y, Chen CF, Chang R, Zhou J, and Scheuermann RH. . pmid:17092991. PubMed HubMed [Bioinformatics_2007_Jan_15_23_207_214_Modular_organization_of_protein_interaction_networks]
All Medline abstracts: PubMed HubMed

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