|
Mohammad Haj Dezfulian, PhD
Assistant Professor
Department of Pathology and Laboratory Medicine
Institute for Immunology and Immune Health
Parker Institute for Cancer Immunotherapy
Institute for Diabetes, Obesity, and Metabolism
University of Pennsylvania
Office: 15-106
Lab: 15-400
Address: 3600 Civic Center Blvd, Philadelphia, PA 19104
W: Lab Website
Patents
Methods And Compositions for Identifying Epitopes. WO/2018/227091
Link
This patent describes the development of TScan-I and TScan-II platforms, which are the core innovations at TScan Therapeutics.
Publications
Search Pubmed for an updated list of publications
Peer Reviewed
- Sardari, S. and Dezfulian, M.H. (2005). Evaluation of SAR for amphotericin B derivatives by artificial neural network. Tropical Journal of Pharmaceutical Research. PDF
- Sardari, S. and Dezfulian, M.H. (2007). Cheminformatics in anti-infective agent discovery. Mini Reviews in Medicinal Chemistry. PDF
- Dezfulian, M.H., Soulliere, D.M., Dhaliwal, R.K., Sareen, M. and Crosby, W.L. (2012). The SKP1-like gene family of Arabidopsis exhibits a high degree of differential gene expression and gene product interaction during development. PLOS ONE. Link
- Maleki, M., Dezfulian, M.H. and Rueda, L. (2015). A computational domain-based feature grouping approach for prediction of stability of SCF ligases. Bioinformatics and Biomedical Engineering. Link
- Khalili, S., Rahbar, M.R., Dezfulian, M.H. and Jahangiri, A. (2015). In silico analyses of Wilms’ tumor protein to designing a novel multi-epitope DNA vaccine against cancer. Journal of Theoretical Biology. Link
- Dezfulian, M.H., Jalili, E., Roberto, D.K.A., Moss, B.L., Khoo, K., Nemhauser, J.L. and Crosby, W.L. (2016). Oligomerization of SCFTIR1 is essential for Aux/IAA degradation and auxin signaling in Arabidopsis. PLOS Genetics. Link
- Dezfulian, M.H., Foreman, C., Jalili, E., Pal, M., Dhaliwal, R.K., Roberto, D.K.A., Imre, K.M., Kohalmi, S.E. and Crosby, W.L. (2017). Acetolactate synthase regulatory subunits play divergent and overlapping roles in branched-chain amino acid synthesis and Arabidopsis development. BMC Plant Biology. Link
- Kula, T., Dezfulian, M.H., Wang, C.I., Abdelfattah, N.S., Hartman, Z.C., Wucherpfennig, K.W., Lyerly, H.K. and Elledge, S.J. (2019). T-Scan: A genome-wide method for the systematic discovery of T cell epitopes. Cell. Link
- Highlighted in Science Translational Medicine, Nature Methods and Trends in Immunology.
- Meng, Q., Xie, S., Gray, G.K., Dezfulian, M.H., Gandarilla, O., Li, W., Huang, L., Akshinthala, D.C., Ferrer, E., Conahan, C., Perea Del Pino, S., Grossman, J., Elledge, S.J., Hidalgo, M. and Muthuswamy, S.K. (2021). Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids. Journal for ImmunoTherapy of Cancer. Link
- Naxerova, K., Di Stefano, B., Makofske, J.L., Watson, E.V., de Kort, M.A., Martin, T.D., Dezfulian, M.H., Ricken, D., Wooten, E.C., Kuroda, M.I., Hochedlinger, K. and Elledge, S.J. (2021). Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes & Development. Link
- Dezfulian, M.H., Kula, T., Pranzatelli, T., Kamitaki, N., Meng, Q., Khatri, B., Perez, P., Xu, Q., Chang, A., Kohlgruber, A.C., Leng, Y., Jupudi, A.A., Joachims, M.L., Chiorini, J.A., Lessard, C.J., Farris, A.D., Muthuswamy, S.K., Warner, B.M. and Elledge, S.J. (2023). TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell. Link
- Highlighted in Nature Methods, Cell Reports Methods and Cancer Immunology Research.
- Kohlgruber, A.C., Dezfulian, M.H., Sie, B.M., Wang, C.I., Kula, T., Laserson, U., Larman, H.B. and Elledge, S.J. (2025). High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nature Biotechnology. Link
- Stetsenko, V., Gail, D.P., Reba, S., Suzart, V.G., Sandhu, A.K., Sette, A., Dezfulian, M.H., Lindestam Arlehamn, C.S. and Carpenter, S.M. (2025). Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses. Journal of Experimental Medicine. Link
- Pranzatelli, T.J.F., Perez, P., Ku, A., Matuck, B., Huynh, K., Sakai, S., Abed, M., Jang, S.-I., Yamada, E., Dominick, K., Ahmed, Z., Oliver, A.J., Bogle, R., Easter, Q.T., Baer, A.N., Pelayo, E., Khavandgar, Z., Kleiner, D.E., Magone, M.T., Gupta, S., Lessard, C., Farris, A.D., Burbelo, P.D., Martin, D., Morell, R.J., Zheng, C., Rachmaninoff, N., Maldonado-Ortiz, J., Tyc, K.M., Qu, X., Aure, M., Dezfulian, M.H., Lake, R., Teichmann, S.A., Barber, D.L., Tsoi, L.C., Sowalsky, A.G., Liu, J., Gudjonsson, J., Byrd, K.M., Johnson, P.L.F., Chiorini, J.A. and Warner, B.M. (2026). GZMK+ CD8+ T cells target a specific acinar cell type in Sjögren’s disease. Annals of the Rheumatic Diseases. Link
Non Peer Reviewed
1. Sardari, S. and Dezfulian, MH. The Eastern Mediterranean Health Genomics and Biotechnology Network Critical for the Region. (2006) Genetic Engineering News Link
|
