User:Mbennie/Notebook/Papers and Books/Ron Weiss
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- Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 2005 Apr 28;434(7037):1130-4. DOI:10.1038/nature03461 |
- Built three types of cells that express fluorescent protein when presented with a certain concentration of autoinducer (high, medium, low)
- Mixture of cells can produce a bullseye when a sender cell is place in the middle
- Bi-directional communication might be an interesting topic to investigate
- Use same mechanism, but make cells express different protein such as adhesin (cells only stick together when they detect autoinducer)
- Yokobayashi Y, Weiss R, and Arnold FH. Directed evolution of a genetic circuit. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16587-91. DOI:10.1073/pnas.252535999 |
- Paper discusses purposely mutating pathways to optimize genetic circuits
- Fluorescent screening used to discover which mutations made the nonfunctional gate work as intended
- Good method, but no apparent future work