User:Marie-Eve Val

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Vibrio cholerae
Vibrio cholerae
site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome
site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome
Genome rearrangement events occuring within a single colony
Genome rearrangement events occuring within a single colony

Marie-Eve VAL
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
28 rue du Dr. Roux
75724 PARIS cedex 15
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Research interests

I am a research associate in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, we developed a site-specific recombination-based engineering tool, which provides us with a powerful mean to massively reorganize in principle any prokaryotic genome.


Professional Training


  1. Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O, and Mazel D. . pmid:27152358. PubMed HubMed [Science-Advances-2016]
    A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae

  2. Soler-Bistué A, Mondotte JA, Bland MJ, Val ME, Saleh MC, and Mazel D. . pmid:25875621. PubMed HubMed [PLoS-Genet-2015]
    Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity

  3. Val ME, Soler-Bistué A, Bland MJ, and Mazel D. . pmid:25460805. PubMed HubMed [Curr-Opin-Microbiol-2014]
    Management of multipartite genomes: the Vibrio cholerae model

  4. Val ME, Kennedy SP, Soler-Bistué AJ, Barbe V, Bouchier C, Ducos-Galand M, Skovgaard O, and Mazel D. . pmid:24308271. PubMed HubMed [Molecular-Microbioloy-2014]
    Fuse or die: how to survive the loss of Dam in Vibrio cholerae

  5. Val ME, Skovgaard O, Ducos-Galand M, Bland MJ, and Mazel D. . pmid:22253612. PubMed HubMed [PLOS-Genetics-2012]
    Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues

  6. Das B, Bischerour J, Val ME, and Barre FX. . pmid:20133778. PubMed HubMed [PNAS-2010]
    Molecular keys of the tropism of integration of the cholera toxin phage

  7. Génolevures Consortium, Souciet JL, Dujon B, Gaillardin C, Johnston M, Baret PV, Cliften P, Sherman DJ, Weissenbach J, Westhof E, Wincker P, Jubin C, Poulain J, Barbe V, Ségurens B, Artiguenave F, Anthouard V, Vacherie B, Val ME, Fulton RS, Minx P, Wilson R, Durrens P, Jean G, Marck C, Martin T, Nikolski M, Rolland T, Seret ML, Casarégola S, Despons L, Fairhead C, Fischer G, Lafontaine I, Leh V, Lemaire M, de Montigny J, Neuvéglise C, Thierry A, Blanc-Lenfle I, Bleykasten C, Diffels J, Fritsch E, Frangeul L, Goëffon A, Jauniaux N, Kachouri-Lafond R, Payen C, Potier S, Pribylova L, Ozanne C, Richard GF, Sacerdot C, Straub ML, and Talla E. . pmid:19525356. PubMed HubMed [Genome-Research-2009]
    Comparative genomics of protoploid Saccharomycetaceae

  8. Val ME, Kennedy SP, El Karoui M, Bonné L, Chevalier F, and Barre FX. . pmid:18818731. PubMed HubMed [PLOS-Genetics-2008]
    FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae

  9. Val ME, Bouvier M, Campos J, Sherratt D, Cornet F, Mazel D, and Barre FX. . pmid:16109379. PubMed HubMed [Molecular-Cell-2005]
    The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae

All Medline abstracts: PubMed HubMed

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