User:Juergen Bosch

Contact Info

• Jürgen Bosch
• Johns Hopkins University
• 615N Wolfe Street
• Bloomberg School of Public Health
• Baltimore, MD, USA
• Email me through OpenWetWare

I work at Johns Hopkins University. I learned about OpenWetWare from the MMV website/Newsletter, and I've joined because we work on Malaria as well, trying to discover novel drug targets and developing small molecule inhibitors that may develop from probes to potential interesting starting points for leads..

Education

• 2003, PhD, Max Planck Institute for Biochemistry, Munich, Germany
• 2004-2008, Postdoctoral Fellow, University of Washington, Seattle,WA, USA
• 2009- present, Assistant Professor, Johns Hopkins University, Baltimore, MD, USA

Research interests

1. Bosch Lab JHU website
2. Plasmodium Invasion machinery
3. Autophagy in Plasmodium
4. Virtual screening

Publications

1. Reiter K, Mukhopadhyay D, Zhang H, Boucher LE, Kumar N, Bosch J, and Matunis MJ. Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. J Biol Chem. 2013 Sep 27;288(39):27724-36. DOI:10.1074/jbc.M113.498410 |
2. Boucher LE and Bosch J. Development of a multifunctional tool for drug screening against plasmodial protein-protein interactions via surface plasmon resonance. J Mol Recognit. 2013 Oct;26(10):496-500. DOI:10.1002/jmr.2292 |
3. Morris F, Vierling R, Boucher L, Bosch J, and Freel Meyers CL. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem. 2013 Jul 22;14(11):1309-15. DOI:10.1002/cbic.201300187 |
4. Pal-Bhowmick I, Andersen J, Srinivasan P, Narum DL, Bosch J, and Miller LH. Binding of aldolase and glyceraldehyde-3-phosphate dehydrogenase to the cytoplasmic tails of Plasmodium falciparum merozoite duffy binding-like and reticulocyte homology ligands. mBio. 2012;3(5). DOI:10.1128/mBio.00292-12 |
5. Hain AU, Weltzer RR, Hammond H, Jayabalasingham B, Dinglasan RR, Graham DR, Colquhoun DR, Coppens I, and Bosch J. Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction. J Struct Biol. 2012 Dec;180(3):551-62. DOI:10.1016/j.jsb.2012.09.001 |
6. Bosch J, Paige MH, Vaidya AB, Bergman LW, and Hol WG. Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. J Struct Biol. 2012 Apr;178(1):61-73. DOI:10.1016/j.jsb.2012.02.009 |
7. Tooley JE, Khangulov V, Lees JP, Schlessman JL, Bewley MC, Heroux A, Bosch J, and Hill RB. The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1310-5. DOI:10.1107/S1744309111029368 |
8. Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, and Hol WG. Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem. 2009;9(18):1678-87. DOI:10.2174/156802609790102383 |
9. Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, and Hol WG. Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol. 2008;426:497-513. DOI:10.1007/978-1-60327-058-8_33 |
10. Bosch J, Turley S, Roach CM, Daly TM, Bergman LW, and Hol WG. The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery. J Mol Biol. 2007 Sep 7;372(1):77-88. DOI:10.1016/j.jmb.2007.06.016 |
11. Bosch J, Buscaglia CA, Krumm B, Ingason BP, Lucas R, Roach C, Cardozo T, Nussenzweig V, and Hol WG. Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7015-20. DOI:10.1073/pnas.0605301104 |
12. Bosch J, Tamura T, Tamura N, Baumeister W, and Essen LO. The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology. Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):179-87. DOI:10.1107/S0907444906045471 |
13. Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, and Hol WG. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem. 2006 Oct 5;49(20):5939-46. DOI:10.1021/jm060429m |
14. Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, and Hol WG. Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. DOI:10.1073/pnas.0510907103 |
15. Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, and Hol WG. Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum. Proteins. 2006 Feb 1;62(2):338-42. DOI:10.1002/prot.20764 |
16. Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, and Hol WG. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins. 2006 Mar 15;62(3):570-7. DOI:10.1002/prot.20801 |
17. Bosch J, Tamura T, Bourenkov G, Baumeister W, and Essen LO. Purification, crystallization, and preliminary X-ray diffraction analysis of the Tricorn protease hexamer from Thermoplasma acidophilum. J Struct Biol. 2001 Apr;134(1):83-7. DOI:10.1006/jsbi.2001.4360 |

18. Hain A.U.P., Bosch J. Autophagy in Plasmodium, a multifunctional pathway?

    CSBJ, Volume No: 8, Issue: 11, August 2013, e201308002, http://dx.doi.org/10.5936/csbj.201308002

19. Jayabalasingham B.,Voss C.,Ehrenman K., Romano J.D., Smith M.E.,Fidock D.A., Bosch J. and Coppens I. Characterization of the Atg8-conjugation system in two Plasmodium species with special focus on the liver stage: Possible linkage between the apicoplastic and autophagic systems? (accepted at Autophagy)

    leave a comment about a paper here

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