User:Jarle Pahr/Nested feedback loops

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Notes on nested feedback loops:

Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions. Onn Brandman1, James E. Ferrell Jr, Rong Li and Tobias Meyer1.

They "created models of positive feedback switches containing either a single positive feedback loop (Fig. 2A) or two interlinked loops (Fig. 2B)."

Citing articles:

Models of signalling networks – what cell biologists can gain from them and give to them:

Building biological memory by linking positive feedback loops:

Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks:

Tuning the Activation Threshold of a Kinase Network by Nested Feedback Loops:

Feedback Loops Shape Cellular Signals in Space and Time:

Subnetwork analysis reveals dynamic features of complex (bio)chemical networks:

Mechanistic mathematical model of polarity in yeast:

The Cell Cycle Switch Computes Approximate Majority:

Asymmetric positive feedback loops reliably control biological responses.:

Unraveling the design principle for motif organization in signaling networks.:

Simple rules for complex processes: new lessons from the budding yeast cell cycle.:

A Comparison of Mathematical Models for Polarization of Single Eukaryotic Cells in Response to Guided Cues:

Positive-feedback loops in cell cycle progression.

Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory.

Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses.

Coupled feedback loops form dynamic motifs of cellular networks.

Boolean dynamics of biological networks with multiple coupled feedback loops.


Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times.:

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