User:Ernesto Perez-Rueda/Notebook/Transcription Factors/Entry Base

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Gene regulation is crucial for optimal processes in the cell and to adapt metabolic responses to diverse environmental conditions. At this context, regulation of gene expression at transcriptional level allow all the organisms modulate the synthesis of specific genes depending of the metabolic requirements, such as stress or food availability. Therefore, bacteria that exhibit free-living lifestyles, such as Pseudomonas aeruginosa or Escherichia coli, bear a much larger number and variety of genes encoding transcriptional regulators than intracellular pathogens that thrive in more stable biotopes (Pérez-Rueda et al. 2009, 2018). The regulation of protein production at transcription initiation affects the first steps in the synthesis of RNA, optimizing, probably, energetic requirements.