User:Cookb

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My Info

Brian L. Cook
500 Technology Square -- NE47-380
Cambridge, MA 02139

Office: (617) 324-1947
Fax: (617) 258-5239
Email: cookb@mit.edu

Ph.D. Candidate
MIT Biological Engineering
Zhang Lab (Center for Biomedical Engineering)

About Me

Currently I'm in my 4th year of graduate school, researching smell (olfactory receptors).  
I'm currently serving as a graduate advisor for the 2007 MIT iGEM team.  
For more info on iGEM, check out the iGEM 2007 Page!

1. Jacquier V, Pick H, and Vogel H. Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds. J Neurochem 2006 Apr; 97(2) 537-44. doi:10.1111/j.1471-4159.2006.03771.x pmid:16539658. PubMed HubMed [vogel2006]
2. Chelikani P, Reeves PJ, Rajbhandary UL, and Khorana HG. The synthesis and high-level expression of a beta2-adrenergic receptor gene in a tetracycline-inducible stable mammalian cell line. Protein Sci 2006 Jun; 15(6) 1433-40. doi:10.1110/ps.062080006 pmid:16731977. PubMed HubMed [khorana2006]
3. Reeves PJ, Callewaert N, Contreras R, and Khorana HG. Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proc Natl Acad Sci U S A 2002 Oct 15; 99(21) 13419-24. doi:10.1073/pnas.212519299 pmid:12370423. PubMed HubMed [khorana2002]
4. Reeves PJ, Kim JM, and Khorana HG. Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants. Proc Natl Acad Sci U S A 2002 Oct 15; 99(21) 13413-8. doi:10.1073/pnas.212519199 pmid:12370422. PubMed HubMed [khorana2002b]
5. Reeves PJ, Thurmond RL, and Khorana HG. Structure and function in rhodopsin: high level expression of a synthetic bovine opsin gene and its mutants in stable mammalian cell lines. Proc Natl Acad Sci U S A 1996 Oct 15; 93(21) 11487-92. pmid:8876162. PubMed HubMed [khorana1996]
6. Gat U, Nekrasova E, Lancet D, and Natochin M. Olfactory receptor proteins. Expression, characterization and partial purification. Eur J Biochem 1994 Nov 1; 225(3) 1157-68. pmid:7957207. PubMed HubMed [gat1994]
7. Breer H. Olfactory receptors: molecular basis for recognition and discrimination of odors. Anal Bioanal Chem 2003 Oct; 377(3) 427-33. doi:10.1007/s00216-003-2113-9 pmid:12898108. PubMed HubMed [breer2003review]
8. Godfrey PA, Malnic B, and Buck LB. The mouse olfactory receptor gene family. Proc Natl Acad Sci U S A 2004 Feb 17; 101(7) 2156-61. doi:10.1073/pnas.0308051100 pmid:14769939. PubMed HubMed [godfrey2004]
9. Malnic B, Godfrey PA, and Buck LB. The human olfactory receptor gene family. Proc Natl Acad Sci U S A 2004 Feb 24; 101(8) 2584-9. pmid:14983052. PubMed HubMed [malnic2004]
10. Hoover DM and Lubkowski J. DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis. Nucleic Acids Res 2002 May 15; 30(10) e43. pmid:12000848. PubMed HubMed [hoover2002]
11. Stemmer WP, Crameri A, Ha KD, Brennan TM, and Heyneker HL. Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene 1995 Oct 16; 164(1) 49-53. pmid:7590320. PubMed HubMed [stemmer1995]
12. Seddon AM, Curnow P, and Booth PJ. Membrane proteins, lipids and detergents: not just a soap opera. Biochim Biophys Acta 2004 Nov 3; 1666(1-2) 105-17. doi:10.1016/j.bbamem.2004.04.011 pmid:15519311. PubMed HubMed [seddon2004]
13. Spehr M, Schwane K, Riffell JA, Zimmer RK, and Hatt H. Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm. Mol Cell Endocrinol 2006 May 16; 250(1-2) 128-36. doi:10.1016/j.mce.2005.12.035 pmid:16413109. PubMed HubMed [spehr2006]