User:Campbell McInnes
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- Campbell McInnes
- Assistant Professor. Medicinal Chemistry
- University of South Carolina
- South Carolina College of Pharmacy
- CLS 715, 715 Sumter St
- Columbia, SC, 29208, USA
- email: mcinnes@sccp.sc.edu
Education
- 1991, PhD, University of Edinburgh
- 1986, B.Sc, University of Guelph
Research interests
- Structure-guided Drug Discovery and Design
- Protein Kinase Inhibitors
- Anti-cancer therapeutics
Laboratory websites
South Carolina College of Pharmacy
http://www.sccp.sc.edu/profile.aspx?guid=f95cf302-70bd-4b52-9bee-daf9b86fa8ae
Publications
- McIntyre NA, McInnes C, Griffiths G, Barnett AL, Kontopidis G, Slawin AM, Jackson W, Thomas M, Zheleva DI, Wang S, Blake DG, Westwood NJ, and Fischer PM. Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors. J Med Chem. 2010 Mar 11;53(5):2136-45. DOI:10.1021/jm901660c |
- Kontopidis G, Andrews MJ, McInnes C, Plater A, Innes L, Renachowski S, Cowan A, and Fischer PM. Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design. ChemMedChem. 2009 Jul;4(7):1120-8. DOI:10.1002/cmdc.200900093 |
- Kirkland LO and McInnes C. Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics. Biochem Pharmacol. 2009 May 15;77(10):1561-71. DOI:10.1016/j.bcp.2008.12.022 |
- McInnes C. Progress in the evaluation of CDK inhibitors as anti-tumor agents. Drug Discov Today. 2008 Oct;13(19-20):875-81. DOI:10.1016/j.drudis.2008.06.012 |
- McInnes C. Virtual screening strategies in drug discovery. Curr Opin Chem Biol. 2007 Oct;11(5):494-502. DOI:10.1016/j.cbpa.2007.08.033 |
- Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, and Fischer PM. REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. Chembiochem. 2006 Dec;7(12):1909-15. DOI:10.1002/cbic.200600189 |
- McInnes C, Mazumdar A, Mezna M, Meades C, Midgley C, Scaerou F, Carpenter L, Mackenzie M, Taylor P, Walkinshaw M, Fischer PM, and Glover D. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. DOI:10.1038/nchembio825 |
