User:Alexander Pertsemlidis

Contact Info

Alexander Pertsemlidis (an artistic interpretation)

• Alexander Pertsemlidis, PhD
• UT Health Science Center at San Antonio
• Greehey Children's Cancer Research Institute
• 8403 Floyd Curl Drive
• San Antonio, Texas 78229-3900
• Email me through OpenWetWare

My lab is part of the CCRI and CTRC at The University of Texas Health Science Center in San Antonio. I learned about OpenWetWare from through graduate students in the lab.

Education

• 1995, PhD, UC Berkeley
• 1988, MS, The University of Michigan
• 1987, AB, Princeton University

Research interests

• microRNA regulation of drug sensitivity in non-small cell lung cancer
• variation in microRNAs and human disease

Publications

1. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, and Hobbs HH. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008 Dec;40(12):1461-5. DOI:10.1038/ng.257 |
2. Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, and Sunyaev SR. Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. Am J Hum Genet. 2007 Dec;81(6):1298-303. DOI:10.1086/522497 |
3. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, and Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007 Jun 8;316(5830):1488-91. DOI:10.1126/science.1142447 |
4. Pertsemlidis A, Zelinka J, Fondon JW 3rd, Henderson RK, and Otwinowski Z. Bayesian statistical studies of the Ramachandran distribution. Stat Appl Genet Mol Biol. 2005;4:Article35. DOI:10.2202/1544-6115.1165 |
5. Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, and Hobbs HH. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet. 2006 Mar;78(3):410-22. DOI:10.1086/500615 |
6. Cohen JC, Pertsemlidis A, Fahmi S, Esmail S, Vega GL, Grundy SM, and Hobbs HH. Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1810-5. DOI:10.1073/pnas.0508483103 |
7. Lancman JJ, Caruccio NC, Harfe BD, Pasquinelli AE, Schageman JJ, Pertsemlidis A, and Fallon JF. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec;234(4):948-60. DOI:10.1002/dvdy.20591 |
8. Ferguson DA, Muenster MR, Zang Q, Spencer JA, Schageman JJ, Lian Y, Garner HR, Gaynor RB, Huff JW, Pertsemlidis A, Ashfaq R, Schorge J, Becerra C, Williams NS, and Graff JM. Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap. Cancer Res. 2005 Sep 15;65(18):8209-17. DOI:10.1158/0008-5472.CAN-04-3726 |
9. Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, and Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet. 2005 Feb;37(2):161-5. DOI:10.1038/ng1509 |
10. Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, and Hobbs HH. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science. 2004 Aug 6;305(5685):869-72. DOI:10.1126/science.1099870 |
11. Schageman JJ, Horton CJ, Niu S, Garner HR, and Pertsemlidis A. ELXR: a resource for rapid exon-directed sequence analysis. Genome Biol. 2004;5(5):R36. DOI:10.1186/gb-2004-5-5-r36 |

Useful links

• Introductory tutorial
• OpenWetWare help pages