THF
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Contents |
Name
Tetrahydrofuran
Use
- Heterocyclic compound implicated in organic synthesis of unnatural amino acids, and most importantly as a miscible (anhydrous) reagent to synthetize N-substituted phenoxyalkylamines (ligands) using orthogonal (multi-step) catalysis of dicarboxilic protected C=N ions (imine) in nucleophilic carbonyl addition reactions.
- In biochemical warfare: See also Schiff base for an explanation to rationalize the evidences of THF/imide functions in hydrazide based chemical spraying. Most certainly a human life degrading psychochemical agent composed of a N-substituted heterocyclic carbanion with an aryl(alkyl) group/bond in the 2nd primary position of the hydroxyl (NH2!) "syn" optical isomer . Thus, THF/imide based NHC may be reasonable compounds to administrate atypical psychotic drugs to poorly informed and knowledgeable population on the false assumptions of saving humanity from self-destruction. -ER, February 27 2013
- Keywords: hydrazide, THF, Schiff base, 2-phenyl-N-methyl-amine, PD, PVOH, PVA
N-substituted (cis/trans) phenoxyalkylation using Michael reaction of complex amino acids
- For details on 2-phenethylamine based DNA protection group, look here.
- a "alkane isomerisation" type of organic catalysis 1
- Etienne Robillard 10:35, 15 January 2013 (EST) Can aromatic nucleophilic substitution of a disubstituted phenoxyalkylamine produce para/ortho opioid ligand (L-dopamine for example) ? In this case, verify if the N heterocycle ring is acting as the nucleophile (R) reagent in presence of an aldehyde...
- Etienne Robillard 10:35, 15 January 2013 (EST) See also "Michael reaction" for a proper explanation.. :)
- Etienne Robillard 10:35, 15 January 2013 (EST) Can aromatic nucleophilic substitution of a disubstituted phenoxyalkylamine produce para/ortho opioid ligand (L-dopamine for example) ? In this case, verify if the N heterocycle ring is acting as the nucleophile (R) reagent in presence of an aldehyde...
- isopropanol can donate proton -- an aldehyde like solvent?
- Etienne Robillard 10:35, 15 January 2013 (EST) Can THF donate stuff with nucleophilic rings? ie cyclohexanoyl
- alkane isomerisation = organic synthesis: L-dopamine, cyclohexylamine, etc..
- Ethics of producing novel opioid receptor agonist compounds for human-specific psychotropic experiments?
- Etienne Robillard 10:35, 15 January 2013 (EST) Heck, is there a possibility theses novel psychotropic compounds be used by terrorist groups to terrorize unwary citizens with psychological warfare using unconventional (synthetic) "devices" ?
related psychochemicals
- Benzylamine (2-phenyl-N-methyl-amine)
- Piperidine ?
References
1. Kim J., Recent Advances in Asymmetric Phase-Transfer-Catalysis, 2011 http://stoltz.caltech.edu/seminars/2011_Kim.pdf p. [1-25]
See also
- Mannich/Michael reaction
- Pictet-Spengler reaction
- DMF - A THF analog (N,N-dimethylformamide)
- Ethanamine
- Wikipedia:Tetrahydrofolic acid (THF)


