Kafatos:Fotis C. Kafatos

Click here to visit our NEW WEBSITE

The content below is most likely out of date. We also have a new lean and mean openwetware area.

Fotis C. Kafatos Division of Cell & Molecular Biology South Kensington Campus, SAF London, SW7 2AZ UK f.kafatos[at]imperial.ac.uk

I am one of the PIs in the Kafatos/Christophides Lab at Imperial College, London and Honorary President of the European Research Council as well as Member of its Scientific Council.

Wikipedia Entry
Watch an interview video of me (interviewer: George Dimopoulos, PhD hosted at the JHSPH)
Imperial faculty webpage and Contact Details

Education

1965 PhD, Biology Harvard University, USA.
1962 MA, Biology Harvard University, USA.
1961 AB, Zoology (High Honours) Cornell University, USA.
Primary and secondary education in Crete

Academic Appointments

2007 - present Adjunct Professor of Immunology & Infectious Diseases, Harvard School of Public Health
2005 - present Professor, Chair of Immunogenomics, Imperial College, London, UK.
1993 - 2005 Director General, and group leader at European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
1982 - 1993 Founder and Director, Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece.
1982 - present Professor of Biology (part-time), University of Crete, Greece, (on leave).
1972 - 1982 Professor of Biology (part-time), University of Athens, Greece.
1978 - 1981 Chair, Cellular and Developmental Biology, Harvard University, USA.
1969 - 1994 Professor of Biology, Harvard University, USA.
1965 - 1969 Assistant Professor of Biology, Harvard University, USA.
1965 Instructor of Biology, Harvard University, USA.

Honours

[show][hide]

President of the European Research Council and Chairman of its Scientific Council, 2007 - 2011
Fondation Louis Jeantet – 25th Anniversary Special Prize, 2008
Member, European Academy of Sciences and Arts, 2007
Uni-Heidelberg Grosse Universitats Medal, 2005
Medal of Honour, City of Heraklion, Crete, 2004
“Bundesverdienstkreuz 1. Klasse”, awarded by the President of the Federal Republic of Germany, 2004
Medal “Taxiarchis of Phoenix”, awarded by the President of the Hellenic Republic, for contributions to Science, Culture and Society, 2003
Foreign Member of the Royal Society of London, 2003
Member, Pontifical Academy of Sciences, 2003
Foreign Member of the French Academy of Sciences, 2002
Honorary Medal for Distinction in Biology, Academy of Athens, 2000
Honorary Professor, University of Heidelberg, Germany 2000
G.J. Mendel Honorary Gold Medal for Merit in the Biological Sciences, Academy of Sciences of the Czech Republic, 1995
Member, Academia Europaea, 1991
Member, National Academy of Science, USA, 1982
Fellow, American Academy of Arts and Sciences, 1980

Honorary Doctorates

• Agricultural University of Athens 1992
• University Thessaloniki 1994
• Université Louis Pasteur, Strasbourg 2002
• University of Thrace 2004
• Cyprus University of Technology 2008

Board Memberships (partial list)

[show][hide]

2004 – present

Sanger Institute, Hinxton (UK), Scientific Advisory Board

2004 – 2007

International Risk Governance Council (Geneva), Scientific and Technical Council

2004 – present

Centro Nacional de Investigaciones Oncológicas Carlos III (Spain), Scientific Advisory Board

2003 – present

Bill and Melinda Gates Foundation (Seattle), Scientific Board of “Grand Challenges in Global Health Initiative”

2003 – present

Hellenic Pasteur Institute (Athens), Scientific Committee

2002 – present

Temasek Life Sciences Laboratory (Singapore), International Scientific Advisory Board

2002 – present

Flanders Interuniversity Institute for Biotechnology (VIB), Chair of the Institutional Advisory Board

2002 – 2003

European Intergovernmental Research Organisation Forum (EIROforum), Chair

2002

International Review Panel on Development of Biotechnology in Finland (Chair)

2001 – present

University of Geneva School of Medicine, External Scientific Advisory Board

2000 – present

Institut Pasteur (Paris), External Scientific and Strategic Committee

2000 – present

Sars International Centre for Marine Molecular Biology (Bergen), Scientific Advisory Committee

1998 – 2002

Fondation des Treilles, Scientific Committee

1998 – 2001

Conseil National de la Science, France

1997 – 2002

Fondation Bettencourt Schueller (Paris), Scientific Committee

1995 – present

Max-Planck Institut (Göttingen), Member and Chair of the Fachbeirat

1995 – 2004

Fondation Louis Jeantet de Mèdicine (Geneva), Science Committee

1995 – 2000

Wellcome CRC Institute (Cambridge), International Advisory Board

1994 – present

Institute of Molecular Biology and Biotechnology (Crete), Chair of International Scientific Advisory Board

1994 – 1999

National Science Advisory Board of Greece (Athens)

1991 – 1998

WHO/TDR (Geneva), Steering Committee on Biological Control of Vectors, Molecular Entomology

1991 – 1994

International Centre for Insect Physiology and Ecology (Nairobi), Governing Board/Programme Committee

1988 – 1990

European Molecular Biology Organisation Council

1987 – 1994

Committee for the European Development of Science and Technology – CODEST (European Commission)

1976 – 1993

University of Crete and Foundation of Research and Technology – Hellas Governing Board (overlapping periods)

Publications (partial list)

2009

Error fetching PMID 19028744

2008

Error fetching PMID 18005239

3. Mendes AM, Schlegelmilch T, Cohuet A, Awono-Ambene P, De Iorio M, Fontenille D, Morlais I, Christophides GK, Kafatos FC, and Vlachou D. Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. PLoS Pathog. 2008 May 16;4(5):e1000069. DOI:10.1371/journal.ppat.1000069 |

2007

Error fetching PMID 17253978
Error fetching PMID 17537726
Error fetching PMID 17367780

4. Lawson D, Arensburger P, Atkinson P, Besansky NJ, Bruggner RV, Butler R, Campbell KS, Christophides GK, Christley S, Dialynas E, Emmert D, Hammond M, Hill CA, Kennedy RC, Lobo NF, MacCallum MR, Madey G, Megy K, Redmond S, Russo S, Severson DW, Stinson EO, Topalis P, Zdobnov EM, Birney E, Gelbart WM, Kafatos FC, Louis C, and Collins FH. VectorBase: a home for invertebrate vectors of human pathogens. Nucleic Acids Res. 2007 Jan;35(Database issue):D503-5. DOI:10.1093/nar/gkl960 |
6. Waterhouse RM, Kriventseva EV, Meister S, Xi Z, Alvarez KS, Bartholomay LC, Barillas-Mury C, Bian G, Blandin S, Christensen BM, Dong Y, Jiang H, Kanost MR, Koutsos AC, Levashina EA, Li J, Ligoxygakis P, Maccallum RM, Mayhew GF, Mendes A, Michel K, Osta MA, Paskewitz S, Shin SW, Vlachou D, Wang L, Wei W, Zheng L, Zou Z, Severson DW, Raikhel AS, Kafatos FC, Dimopoulos G, Zdobnov EM, and Christophides GK. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science. 2007 Jun 22;316(5832):1738-43. DOI:10.1126/science.1139862 |
7. Koutsos AC, Blass C, Meister S, Schmidt S, MacCallum RM, Soares MB, Collins FH, Benes V, Zdobnov E, Kafatos FC, and Christophides GK. Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11304-9. DOI:10.1073/pnas.0703988104 |
8. Pindyurin AV, Moorman C, de Wit E, Belyakin SN, Belyaeva ES, Christophides GK, Kafatos FC, van Steensel B, and Zhimulev IF. SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila. J Cell Sci. 2007 Jul 15;120(Pt 14):2344-51. DOI:10.1242/jcs.006007 |

2006

Error fetching PMID 16793259
Error fetching PMID 16756551
Error fetching PMID 16551542
Error fetching PMID 17065316

11. Volz J, Müller HM, Zdanowicz A, Kafatos FC, and Osta MA. A genetic module regulates the melanization response of Anopheles to Plasmodium. Cell Microbiol. 2006 Sep;8(9):1392-405. DOI:10.1111/j.1462-5822.2006.00718.x |
16. Cohuet A, Osta MA, Morlais I, Awono-Ambene PH, Michel K, Simard F, Christophides GK, Fontenille D, and Kafatos FC. Anopheles and Plasmodium: from laboratory models to natural systems in the field. EMBO Rep. 2006 Dec;7(12):1285-9. DOI:10.1038/sj.embor.7400831 |

2005

[show][hide]

Error fetching PMID 16260729
Error fetching PMID 16188883
Error fetching PMID 16113656
Error fetching PMID 16039580
Error fetching PMID 15996894
Error fetching PMID 15928082
Error fetching PMID 15907562
Error fetching PMID 15899967
Error fetching PMID 15894185
Error fetching PMID 15703759
Error fetching PMID 15659062

19. Vontas J, Blass C, Koutsos AC, David JP, Kafatos FC, Louis C, Hemingway J, Christophides GK, and Ranson H. Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure. Insect Mol Biol. 2005 Oct;14(5):509-21. DOI:10.1111/j.1365-2583.2005.00582.x |
20. Sim C, Hong YS, Vanlandingham DL, Harker BW, Christophides GK, Kafatos FC, Higgs S, and Collins FH. Modulation of Anopheles gambiae gene expression in response to o'nyong-nyong virus infection. Insect Mol Biol. 2005 Oct;14(5):475-81. DOI:10.1111/j.1365-2583.2005.00578.x |
22. Meister S, Kanzok SM, Zheng XL, Luna C, Li TR, Hoa NT, Clayton JR, White KP, Kafatos FC, Christophides GK, and Zheng L. Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11420-5. DOI:10.1073/pnas.0504950102 |
24. Vlachou D, Schlegelmilch T, Christophides GK, and Kafatos FC. Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion. Curr Biol. 2005 Jul 12;15(13):1185-95. DOI:10.1016/j.cub.2005.06.044 |
32. Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, Kafatos FC, Janse CJ, Barrell B, Turner CM, Waters AP, and Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005 Jan 7;307(5706):82-6. DOI:10.1126/science.1103717 |

2004

[show][hide]

Error fetching PMID 15567837
Error fetching PMID 15342516
Error fetching PMID 15201288
Error fetching PMID 15199960
Error fetching PMID 14988521
Error fetching PMID 14627712
Error fetching PMID 14627711

37. Vlachou D, Zimmermann T, Cantera R, Janse CJ, Waters AP, and Kafatos FC. Real-time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion. Cell Microbiol. 2004 Jul;6(7):671-85. DOI:10.1111/j.1462-5822.2004.00394.x |
38. Osta MA, Christophides GK, and Kafatos FC. Effects of mosquito genes on Plasmodium development. Science. 2004 Mar 26;303(5666):2030-2. DOI:10.1126/science.1091789 |
39. Blandin S, Shiao SH, Moita LF, Janse CJ, Waters AP, Kafatos FC, and Levashina EA. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Cell. 2004 Mar 5;116(5):661-70. DOI:10.1016/s0092-8674(04)00173-4 |

2003

[show][hide]

Error fetching PMID 12828632
Error fetching PMID 12456678

43. Kumar S, Christophides GK, Cantera R, Charles B, Han YS, Meister S, Dimopoulos G, Kafatos FC, and Barillas-Mury C. The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14139-44. DOI:10.1073/pnas.2036262100 |

2002

[show][hide]

Error fetching PMID 12421699
Error fetching PMID 12364806
Error fetching PMID 12204268
Error fetching PMID 12189180
Error fetching PMID 12117808
Error fetching PMID 12079311
Error fetching PMID 12060762
Error fetching PMID 12058645
Error fetching PMID 12024196
Error fetching PMID 11891134
Error fetching PMID 11792843
Error fetching PMID 11779831
Error fetching PMID 11751581

48. Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, and Kafatos FC. Immunity-related genes and gene families in Anopheles gambiae. Science. 2002 Oct 4;298(5591):159-65. DOI:10.1126/science.1077136 |
49. Zdobnov EM, von Mering C, Letunic I, Torrents D, Suyama M, Copley RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller HM, Dimopoulos G, Law JH, Wells MA, Birney E, Charlab R, Halpern AL, Kokoza E, Kraft CL, Lai Z, Lewis S, Louis C, Barillas-Mury C, Nusskern D, Rubin GM, Salzberg SL, Sutton GG, Topalis P, Wides R, Wincker P, Yandell M, Collins FH, Ribeiro J, Gelbart WM, Kafatos FC, and Bork P. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science. 2002 Oct 4;298(5591):149-59. DOI:10.1126/science.1077061 |
50. Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JM, Wides R, Salzberg SL, Loftus B, Yandell M, Majoros WH, Rusch DB, Lai Z, Kraft CL, Abril JF, Anthouard V, Arensburger P, Atkinson PW, Baden H, de Berardinis V, Baldwin D, Benes V, Biedler J, Blass C, Bolanos R, Boscus D, Barnstead M, Cai S, Center A, Chaturverdi K, Christophides GK, Chrystal MA, Clamp M, Cravchik A, Curwen V, Dana A, Delcher A, Dew I, Evans CA, Flanigan M, Grundschober-Freimoser A, Friedli L, Gu Z, Guan P, Guigo R, Hillenmeyer ME, Hladun SL, Hogan JR, Hong YS, Hoover J, Jaillon O, Ke Z, Kodira C, Kokoza E, Koutsos A, Letunic I, Levitsky A, Liang Y, Lin JJ, Lobo NF, Lopez JR, Malek JA, McIntosh TC, Meister S, Miller J, Mobarry C, Mongin E, Murphy SD, O'Brochta DA, Pfannkoch C, Qi R, Regier MA, Remington K, Shao H, Sharakhova MV, Sitter CD, Shetty J, Smith TJ, Strong R, Sun J, Thomasova D, Ton LQ, Topalis P, Tu Z, Unger MF, Walenz B, Wang A, Wang J, Wang M, Wang X, Woodford KJ, Wortman JR, Wu M, Yao A, Zdobnov EM, Zhang H, Zhao Q, Zhao S, Zhu SC, Zhimulev I, Coluzzi M, della Torre A, Roth CW, Louis C, Kalush F, Mural RJ, Myers EW, Adams MD, Smith HO, Broder S, Gardner MJ, Fraser CM, Birney E, Bork P, Brey PT, Venter JC, Weissenbach J, Kafatos FC, Collins FH, and Hoffman SL. The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002 Oct 4;298(5591):129-49. DOI:10.1126/science.1076181 |
51. Alphey L, Beard CB, Billingsley P, Coetzee M, Crisanti A, Curtis C, Eggleston P, Godfray C, Hemingway J, Jacobs-Lorena M, James AA, Kafatos FC, Mukwaya LG, Paton M, Powell JR, Schneider W, Scott TW, Sina B, Sinden R, Sinkins S, Spielman A, Touré Y, and Collins FH. Malaria control with genetically manipulated insect vectors. Science. 2002 Oct 4;298(5591):119-21. DOI:10.1126/science.1078278 |
56. Dimopoulos G, Christophides GK, Meister S, Schultz J, White KP, Barillas-Mury C, and Kafatos FC. Genome expression analysis of Anopheles gambiae: responses to injury, bacterial challenge, and malaria infection. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8814-9. DOI:10.1073/pnas.092274999 |

2001

[show][hide]

Error fetching PMID 11606751
Error fetching PMID 11553812
Error fetching PMID 11470138
Error fetching PMID 11337470
Error fetching PMID 11311164
Error fetching PMID 11238408
Error fetching PMID 11171396
Error fetching PMID 11154922
Error fetching PMID 11016929

69. Levashina EA, Moita LF, Blandin S, Vriend G, Lagueux M, and Kafatos FC. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Cell. 2001 Mar 9;104(5):709-18. DOI:10.1016/s0092-8674(01)00267-7 |

2000

[show][hide]

Error fetching PMID 11080150
Error fetching PMID 10860981
Error fetching PMID 10841561
Error fetching PMID 10731137
Error fetching PMID 10722387
Error fetching PMID 10708525
Error fetching PMID 10681436
Error fetching PMID 10672074

75. Catteruccia F, Nolan T, Loukeris TG, Blass C, Savakis C, Kafatos FC, and Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. DOI:10.1038/35016096 |