IGEM:IMPERIAL/2007/Ideas/Feasibility/PastIGEM
iGEM (2006) project ideas :
1. oscillator
2. Fluorescent biological photo paper Bio Photo Paper
3. Bio Computer based on Hin/Hix recombinase system (to solve Burnt Pancake problem) link
4. Self Assembling Photographs (using Chemotaxis) link
5. Bacterial Sensing Network Link
6. New Signalling Pathway : Chemotactic Receptors Up an Apartate gradient link
7. Cell to Cell Communication via Conjugation (passing plasmids from one cell to another) link
- Berkely has done this for the past two years now
8. 'Water Colour' EColi (E.Coli expresses flourescent proteins in response to input signals) link
9. Light Directed Systems: link
- light Controlled Chemotaxis
- Edge Detector
- Photofabrication
10. Tri-Metal Biosensor (Vanadium, Iron and Nickel) link
11. 'Quorumtaxis' system : link
- Integrates the quorum-sensing and chemotaxis systems.
- Bacteria engineered with this quorumtaxis system will be able to move towards high concentrations of quorum pheromone
12. unconventional computing as a means of building novel computing paradigms link
13. Hydrogen Sensor link
14. Microscopic Relay Race link
15. Iron Biosensor link
16. link
- Bacterial Dynamo
- Cancer StickyBot
- X-Verter/Predator-Prey System
- Human Encryption
- Protein Cleaving Switch
17. Stem Cell Research link
- PROGRAMMED DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS USING ARTIFICIAL SIGNALING PATHWAYS
18. Bacterial Version of Game Freeze Tag link
19. BioClock , DNA Box , Cell Surface Targeting link
20. Bacterial Night Light link
21. Bacteria that smell pleasant link
22. link
- Repressilator coupled with quorum sensing system
- Luciferase GFP part
- yellow fluorescent protein part
23. Bacterial Thermometer link
24. Edinburgh
- Developing a bacterial bio-sensor that responds to a range of arsenic concentrations and produces a change in pH that can be calibrated in relation with this concentration - maybe lead as suggested - application...
25. Valencia
Combination of Sensor & Actuator
Detection of some stimulus: concentration of some chemical/light intensity - Sensor Grading its "intensity" - pH output based upon colour grading - Actuator
(Similar to the "smoke detector" idea)
26. ETH Zurich
Implementation from the engineer's point of view
Half Adder
- Building logic circuitry : an AND and an XOR Gate
AND Gate: presence of chemical induces the production of an inactive protein, which is activated by a second protein (produced when light is present): the first protein is then activating GFP production
XOR Gate:
a light sensible promoter
a chemical sensible promoter
we would need to give a kind of first signal to the system (to don't have light reactions before a certain moment, otherwise we have to work in a dark room...), an activation signal after the bacterias have grown on the plate
"their" Pro's & Con's
Pro's:
meaningful from an engineering point of view
valuable parts addition to synthetic biology
stepwise proceeding applicable (→ intermediate and partial results!)
experiments visually attractive
probably simple enough
Con's:
cheap copy of “bio-film” project (iGEM 2004)
sensational experiments, have little in common with half adder
maybe that a big vision is lacking
general/practical benefit? (counter-argument: is this required?)
too simple?
Freiburg
- Making a DNA strand fold into a pre-determined form
- Biomaterial/Biofilm concept
27. Tokyo Alliance
- Tic-Tac-Toe playing bacteria - logic processing