Frankel:Force Spectroscopy
From OpenWetWare
'______ 'Force Spectroscopy
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Picking up and unfolding a single protein
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Assembly Nano-mechanics of HIV GP160
GP160mica
Typical sawtooth unfolding pattern of a single molecule of the HIV virion protein GP160. Unfolding forces can be extracted from the sawtooth pattern by applying the worm like chain model.
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Unfolding the ECM protein fibronectin
Sawtooth pattern on the retraction force curve indicating the unfolding of fibronectin. The average rupture force distribution of the protein on mica surface was 85.1 ± 2.7 pN. |
