Endy:Notebook/DNA Methyl Bit/Demethylation

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Papers from Szyf's group claiming the existence of demethylase (MBD2)

  • Promoter-specific activation and demethylation by MBD2/demethylase.
    • Detich N, Theberge J, Szyf M.
    • J Biol Chem. 2002 Sep 27;277(39):35791-4. Epub 2002 Aug 12.
    • PMID: 12177048
  • Extracting DNA demethylase activity from mammalian cells.
    • Szyf M, Bhattacharya SK.
    • Methods Mol Biol. 2002;200:163-76.
    • PMID: 11951651
  • Extracting DNA demethylase activity from mammalian cells.
    • Szyf M, Bhattacharya SK.
    • Methods Mol Biol. 2002;200:155-61.
    • PMID: 11951650
  • Demethylase activity is directed by histone acetylation.
    • Cervoni N, Szyf M.
    • J Biol Chem. 2001 Nov 2;276(44):40778-87. Epub 2001 Aug 27.
    • PMID: 11524416
  • DNA methylation is a reversible biological signal.
    • Ramchandani S, Bhattacharya SK, Cervoni N, Szyf M.
    • Proc Natl Acad Sci U S A. 1999 May 25;96(11):6107-12.
    • PMID: 10339549
  • DNA demethylase is a processive enzyme.
    • 6: Cervoni N, Bhattacharya S, Szyf M.
    • J Biol Chem. 1999 Mar 26;274(13):8363-6.
    • PMID: 10085064
  • A mammalian protein with specific demethylase activity for mCpG DNA.
    • Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M.
    • Nature. 1999 Feb 18;397(6720):579-83.

Papers Arguing Against the Existence of a Demethylase

  • Ng, H. H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., and Bird, A. (1999) Nat. Genet. 23, 58-61
  • Boeke, J., Ammerpohl, O., Kegel, S., Moehren, U., and Renkawitz, R. (2000) J. Biol. Chem. 275, 34963-34967
  • Wade, P. A., Gegonne, A., Jones, P. L., Ballestar, E., Aubry, F., and Wolffe, A. P. (1999) Nat. Genet. 23, 62-66
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