We seek a systems level understanding of immune responses in metazoans using a combination of mechanistic and data driven in silico modeling with experiments.
- Jayajit Das, Activation or Tolerance of Natural Killer Cells is Modulated by Ligand Quality in a Non-Monotonic Manner, Biophysical Journal (2010) [PubMed].
- Sayak Mukherjee et al., Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases, Science Signaling (2013) [PubMed].
Mechanistic Data Driven Models
Can we decipher mechanisms from data driven models of cell signaling?
- Michael Dworkin et al., Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations, Journal of the Royal Society Interface (2012) [PubMed].
Stochastic Processes in Cell Signaling Networks
We aim to uncover basic principles that underlie stochastic noise fluctuations in cell signaling by analyzing minimal models.