Biomod/2014/UANL/enzimas
<html> <head> <title>Enzimas</title> </head> <body>
Enzimas
------------------------------------------------------------------------------------------------------------------------
Introduccion (pequeña explicacion)
------------------------------------------------------------------------------------------------------------------------
Uricasa
------------------------------------------------------------------------------------------------------------------------
Propiedades( Temperatura de transicion ,medios a los que sobrevive , tamaño ,etc)
Reactividad ( cross linking , sitios activos , etc )
MSDS ( ficha tecnica )
Uricase (<a href="http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=1.7.3.3">EC:1.7.3.3</a>) (urate oxidase) [<a href="http://europepmc.org/abstract/MED/3182808">PMID: 3182808</a>] is the peroxisomal enzyme responsible for the degradation of urate into allantoin: Urate + O2 + H2O = 5-hydroxyisourate + H2O2 Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate [<a href="http://europepmc.org/abstract/MED/2594778">PMID: 2594778</a>]. Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved. It is mainly localised in the liver, where it forms a large electron-dense paracrystalline core in many peroxisomes [<a href="http://europepmc.org/abstract/MED/2338140">PMID: 2338140</a>]. The enzyme exists as a tetramer of identical subunits, each containing a possible type 2 copper-binding site [<a href="http://europepmc.org/abstract/MED/2594778">PMID: 2594778</a>]. In legumes, 2 forms of uricase are found: in the roots, the tetrameric form; and, in the uninfected cells of root nodules, a monomeric form, which plays an important role in nitrogen-fixation [<a href="http://europepmc.org/abstract/MED/16593585">PMID: 16593585</a>].
Bibliografía
http://www.ebi.ac.uk/interpro/IEntry?ac=IPR019842
http://www.msdshazcom.com/MSDS/G/genzyme/Uricase-Arthrobacter%20sp..pdf
Ureasa
-----------------------------------------------------------------------------------------------------------------------
Propiedades( Temperatura de transicion ,medios a los que sobrevive , tamaño ,etc)
Reactividad ( cross linking , sitios activos , etc )
MSDS ( ficha tecnica )
---------------------------------------------------------------------------------------------------------------------
Propiedades( Temperatura de transicion ,medios a los que sobrevive , tamaño ,etc)
Reactividad ( cross linking , sitios activos , etc )
MSDS ( ficha tecnica )
</body> </html>
