Biomod/2014/UANL

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Abstract

The need to create nanoscale reactions has been rising, due to the limiting factor of substrate concentration or the conditions in which the reaction takes place. A high concentration of uric acid in the human body can lead to multiple illnesses and uncomfort to the individual that suffers this condition. High levels of this substance can be caused by many situations like an unhealthy diet, a deficient disposal through urination or excessive purine degradation which is the result of illnesses: Lupus Syndrome or Tumor Lysis Syndrome. Because of the wide range of applications, this has a high impact on society, a biocompatible liposome-based nanoreactor was designed, containing specific enzymes which degrade the insoluble uric acid so that it can then be released from the body by urine. With the same core concept, we designed a system for the production of renewable fuel. The reaction is based on the production of diatomic hydrogen from urea in biological waste, resulting in a final compound with a high energy content. Therefore, we show the importance of the development of nanoscale systems, and an overview of their potential applications in public issues.

Objective

Design a nanoreactor of lipid structure with biological catalysts for consecutive reactions. Choosing the most feasible method for producing the nanoreactor.

Goals

Conduct experimentation of nanoreactor production, characterization and enzymatic activity. Locate specific proteins in cell membranes of the kidney and add in the nanoreactor to adhere to the site of action. Find lipids and components compatible with the body for the formation of the lipid vesicles and assess toxicity.


Project Video

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