To synchronize the dynamics triggered by mutual interaction of microtubule and kinesin,
we plan to introduce photo-responsive DNA. By using photo-responsive DNA we can
control duplex formation through photo irradiation. Upon a UV light irradiation photo-
responsive DNA forms duplex and goes back to single strand upon a visible light irradiation(1).
By placing photo-responsive DNA between streptavidin and kinesin, it will be possible to
control the formation of multimeric kinesin. Accordingly the extent of contraction will be
controlled by UV and visible light irradiation.
(Figure1:Control dupllex formation by photo irradiation)
We aim to invent Nano Air Vehicle (NAV) that can fly like bees in the future. NAV means small artificial flying objects. As shown in the picture, bees have two types of cross-shaped fibers in their muscles. The fibers undergo vertical contraction and horizontal relaxation simultaneously. As a result, the bees can flap so quickly(2). Now, the key step in the development of the NAV is to develop a small, but powerful actuator. Therefore, if we can make muscle of bees by utilize the shrinkage of microtubules, we would be able to create very small NAV (small bee like device).
(Figure2:Flapping bee(left),Flapping NAV(right))
NAV is also useful for disaster research. NAV can enter narrow gaps it is possible to collect
information changing natural calamities.
(1) Suzuki, Y.; Endo, M.;Yang, Y.;Sugiyama, H. J. Am. Chem. Soc. 2014, 136, 1714−1717.
(2) Iwamoto,H.; Yagi,N.SPring-8/JASRI.2013,30−31.