Biomod/2013/Todai
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<div id="top"> <figure> <div class="Logo"> <img src="http://openwetware.org/images/9/9c/Logo-OCKver.png" width=730px height=128px> </div> </figure> </div> <br>
<div class="sidebar">
<ul> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai">Home</a> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project">Project</a> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Design">Design</a> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Result">Result</a> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment">Experiment</a> <ul style="list-style-type: none;">
<li>
<a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Contents"> Contents</a></li> <li> <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#PilotStudy"> Pilot Study</a></li> <li> <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Protocols"> Protocols</a></li> </ul> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Team">Team</a> </li> <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Sponsors">Sponsors</a> </li> </ul>
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<h1 class="big-title"><a name="Home"> Home</a></h1> <br>
<article> <h1 class="title"><a name="Oligomeric Cell Killer"> Oligomeric Cell
Killer</a></h1>
<p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific
pore-forming DNA origami drug.</p>
<p class="paragraph">We named this DNA nanostructure "Oligomeric Cell
Killer".</p>
</article>
<br> <article> <h1 class="title"><a name="Abstract"> Abstract</a></h1> <br> <center><iframe width="480" height="360" src="//www.youtube.com/embed/E4RaZ41hJ7w" frameborder="0" allowfullscreen></iframe> </center>
<br>
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height="350px" >
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<p class="paragraph">
Cancer is one of the most common diseases in the world. Chemotherapy is a
popular treatment for cancer, however, it attacks normal cells in addition to
cancer cells, causing severe side effects in some cases. Recently drug
delivery system (DDS) has developed to improve cancer-specificity, but it is
difficult to optimize delivery system for each drug.
</p> <br> <p class="paragraph">
Here, we tried to make a prototype of <span style="color:#e00000">oligomeric
cancer specific pore-forming DNA origami</span>, termed <span
style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might
be a side effects free anti-cancer drug.
</p> <br> <p class="paragraph">
OCKs exist in a monomeric form in solution and penetrate into the cell
randomly. Cancer specific molecules on the membrane of cancer cell trigger
the oligomerization of OCK, resulting in the pore-forming and <span
style="color:#e00000">subsequent death of cancer cell</span>. In contrast,
the OCKs keep monomeric form in the normal cell, allowing <span
style="color:#e00000">the normal cell to keep alive</span>.
Our study might be the basis for cancer specific drug. </p> <br>
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