Biomod/2012/UPC/GenomicsNuts

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Response biomolecular gravity sensors in the presence of magnetic fields

David A. Laván1,2, Diego Orihuela2, Luis Moreno2, Gabriela Sanabria2, Marcos Moroto3, Andrés Guillen4, Julio Valdivia-Silva5, Juana del Valle6, Miguel Díaz7


1International Institute of the Cancer and Pain Lima – Perú; 2Cytogenetic Lab, School of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima – Perú; 3Department of Pharmacology and Therapeutics, School of Medicine, Universidad Autónoma de Madrid España; 4Universidad Cayetano Heredia Lima Perú; 5Space Science & Astrobiology Division, NASA Ames Research Center, USA; 6School of Medicine, Universidad de Ciencias Aplicadas Lima Perú; 7Service of Radiology, Social Insurance of Health Lima Perú.

Abstract


Currently different theories describe the presence of gravitational fields which has apparently been crucial during the biological evolution and development of the living beings when they emerged from the sea towards the continental land. Our work describes the design and development of a set of possible biomolecular sensors which could detect changes in the gravitational forces and magnetic field. These molecules are expressed by specific genes in Drosophila melanogaster flies and have homologous in the most animal species including human. This group of genes was detected by microarrays techniques comparing RNA sequences extracted from the pupae stage under real or simulated microgravity. Additionally, the development of an correlation algorithm such as a function between the MAS 5.0 and Affymetrix RMA allowed demonstrating that these group of genes meet with all the mathematical and physical conditions of a sensor. We observed that the gene homologues in human of the genes under study are related to various neoplasms. Future applications of these sensors in biotechnology, astrobiology, and medicine are highly encouraging.

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