User:Sunny Sharma: Difference between revisions
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==Contact Info== | ==Contact Info== | ||
*Sunny Sharma | *Sunny Sharma, PhD | ||
* | |||
* | |||
*[[Special:Emailuser/Sunny Sharma|Email me through OpenWetWare]] | *[[Special:Emailuser/Sunny Sharma|Email me through OpenWetWare]] | ||
==Education== | ==Education== | ||
<!--Include info about your educational background--> | <!--Include info about your educational background--> | ||
* | * Postdoctoral Researcher at Department of Cell Biology and Neurosciences. | ||
* Research Fellow at MGH Cancer Center– Harvard Medical School | |||
* Research Associate at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [http://www.uni-frankfurt.de/fb/fb15/english/institute/inst-3-mol-biowiss/] | |||
* 2014, PhD (Biology), Goethe University, Frankfurt am Main, Germany [http://www.uni-frankfurt.de/fb/fb15/english/institute/inst-3-mol-biowiss/] | |||
* 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [http://department.gndu.ac.in/department/molecular.asp] | * 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [http://department.gndu.ac.in/department/molecular.asp] | ||
*2005, BS, Bangalore University, Bangalore, India [http://www.bangaloreuniversity.ac.in/] | *2005, BS, Bangalore University, Bangalore, India [http://www.bangaloreuniversity.ac.in/] | ||
== Awards == | == Awards == | ||
DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - | |||
TFMD (Tosteon and Fund for Medical Discovery) Fellowship. (2018) [http://ecor.mgh.harvard.edu/Default.aspx?node_id=695] | |||
EMBO (European Molecular Biology Organisation) Long Term Fellowship. (2014-2016)[http://www.embo.org/] | |||
DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - 2014) [https://www.daad.de/de/index.html] | |||
CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [http://www.cef-mc.de/index.php?id=2] | CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [http://www.cef-mc.de/index.php?id=2] | ||
ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [http://www. | ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [http://www.icmr.nic.in/] | ||
==Research interests== | ==Research interests== | ||
Line 25: | Line 30: | ||
# Ribosome Biogenesis | # Ribosome Biogenesis | ||
# RNA modifications | # RNA modifications | ||
# Developmental Biology | |||
#Immunology | #Immunology | ||
# Gerontology | # Gerontology | ||
==Publications== | |||
20) Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. [https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa402/5841131] | |||
19) Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs. [https://academic.oup.com/nar/article/48/3/1435/5682905] | |||
18) A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. [http://www.nature.com/articles/s41598-018-30383-z] | |||
17) Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.[https://www.nature.com/articles/s41598-017-09734-9] | |||
16) Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.[http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006804] | |||
15) Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay.[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168873] | |||
14) Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function.[http://www.tandfonline.com/doi/full/10.1080/15476286.2016.1259781] | |||
13) Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. [http://nar.oxfordjournals.org/content/early/2016/04/15/nar.gkw244.abstract] | |||
12)‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification.[http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004%2815%2900139-5] | |||
11) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.[http://nar.oxfordjournals.org/content/early/2015/09/13/nar.gkv895.full] | |||
10) Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.[http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv075.full] | |||
9) Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae.[http://nar.oxfordjournals.org/content/early/2015/02/03/nar.gkv058.abstract] | |||
8) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.[http://www.ncbi.nlm.nih.gov/pubmed/25635753] | |||
7) Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.[http://www.ncbi.nlm.nih.gov/pubmed/25129236] | |||
6) Partial methylation at Am100 in 18S rRNA of baker´s yeast shows ribosome heterogeneity on the level of eukaryotic rRNA modification. Plos One [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089640] | |||
# | 5) Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.[http://nar.oxfordjournals.org/content/early/2013/12/11/nar.gkt1281.full] | ||
# | |||
# | 4) Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.[http://www.ncbi.nlm.nih.gov/pubmed/23913415] | ||
3) Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.[http://www.ncbi.nlm.nih.gov/pubmed/23558746] | |||
2) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.[http://www.ncbi.nlm.nih.gov/pubmed/23180764] | |||
1) Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.[http://www.ncbi.nlm.nih.gov/pubmed/20819262] | |||
==Conferences/ Workshops== | |||
# Plenary talk at 10th Ribosome Synthesis meeting 19th-25th August, Brussels.[http://events.embo.org/15-ribosomes/] | |||
# Seminar at RNA club, 16th October 2013 [http://www.rnaclub.de/img/RNACLUB_20131016.pdf ] | |||
# Plenary talk at Yeast Meeting, Frankfurt 2013 [http://www.yeast-2013.org/faces/index] | |||
# Poster presentation at 18th Annual RNA meeting of the RNA society, Davos, Switzerland [http://www.rnasociety.org/conferences/rna-2013/] | |||
# Seminar at RNA club, 26th September 2012 [http://www.rnaclub.de/img/RNACLUB_20120926.pdf] | |||
# Poster presentation at 9th International Conference on Ribosome Synthesis, Banff, Canada [http://www.rochester.edu/College/BIO/ribosyn2012/] | |||
==Useful links== | ==Useful links== | ||
*http://www.muk.uni-frankfurt.de/53895688/033? | |||
*http://www.yeastgenome.org/ | *http://www.yeastgenome.org/ | ||
*http://www.rnaclub.de | |||
*http://people.biochem.umass.edu/fournierlab/3dmodmap/main.php | *http://people.biochem.umass.edu/fournierlab/3dmodmap/main.php | ||
*http://modomics.genesilico.pl/ | *http://modomics.genesilico.pl/ |
Latest revision as of 11:52, 3 June 2020
Contact Info
- Sunny Sharma, PhD
- Email me through OpenWetWare
Education
- Postdoctoral Researcher at Department of Cell Biology and Neurosciences.
- Research Fellow at MGH Cancer Center– Harvard Medical School
- Research Associate at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [1]
- 2014, PhD (Biology), Goethe University, Frankfurt am Main, Germany [2]
- 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [3]
- 2005, BS, Bangalore University, Bangalore, India [4]
Awards
TFMD (Tosteon and Fund for Medical Discovery) Fellowship. (2018) [5]
EMBO (European Molecular Biology Organisation) Long Term Fellowship. (2014-2016)[6]
DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - 2014) [7]
CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [8]
ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [9]
Research interests
- Ribosome Biogenesis
- RNA modifications
- Developmental Biology
- Immunology
- Gerontology
Publications
20) Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. [10]
19) Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs. [11]
18) A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. [12]
17) Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.[13]
16) Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.[14]
15) Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay.[15]
14) Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function.[16]
13) Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. [17]
12)‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification.[18]
11) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.[19]
10) Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.[20]
9) Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae.[21]
8) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.[22]
7) Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.[23]
6) Partial methylation at Am100 in 18S rRNA of baker´s yeast shows ribosome heterogeneity on the level of eukaryotic rRNA modification. Plos One [24]
5) Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.[25]
4) Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.[26]
3) Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.[27]
2) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.[28]
1) Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.[29]
Conferences/ Workshops
- Plenary talk at 10th Ribosome Synthesis meeting 19th-25th August, Brussels.[30]
- Seminar at RNA club, 16th October 2013 [31]
- Plenary talk at Yeast Meeting, Frankfurt 2013 [32]
- Poster presentation at 18th Annual RNA meeting of the RNA society, Davos, Switzerland [33]
- Seminar at RNA club, 26th September 2012 [34]
- Poster presentation at 9th International Conference on Ribosome Synthesis, Banff, Canada [35]
Useful links
- http://www.muk.uni-frankfurt.de/53895688/033?
- http://www.yeastgenome.org/
- http://www.rnaclub.de
- http://people.biochem.umass.edu/fournierlab/3dmodmap/main.php
- http://modomics.genesilico.pl/
- http://www.rna.icmb.utexas.edu/
- http://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi
- http://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=index