User:Marie-Eve Val

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Vibrio cholerae
Vibrio cholerae
site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome
site-specific recombination-based engineering tool to massively reorganize V. cholerae's genome
Genome rearrangement events occuring within a single colony
Genome rearrangement events occuring within a single colony

Marie-Eve VAL
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
25 rue du Dr. Roux
75724 PARIS cedex 15
Email me through OpenWetWare


Research interests

I am a post-doctoral research fellow in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, I developed a site-specific recombination-based engineering tool, which provides us with a powerful means to massively reorganize in principle any prokaryotic genome. The laboratory of Didier Mazel was an ideal place to initiate such a project since they have developed a large set of genetic tools to work in the vibrios and Didier Mazel has substantial knowledge and experience in site-specific recombination, bacterial genetics and genome analysis.


Professional Training


  1. Genetics pmid=22253612 [Plos]
    Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues.

  2. Das B, Bischerour J, Val ME, and Barre FX. . pmid:20133778. PubMed HubMed [PNAS]
    Molecular keys of the tropism of integration of the cholera toxin phage.

  3. article pmid=16109379


    The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.

  4. article pmid=18818731


    FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae.

  5. article pmid=19525356


    Comparative genomics of protoploid Saccharomycetaceae.

  1. Bikard D, Julié-Galau S, Cambray G, and Mazel D. . pmid:20534632. PubMed HubMed [Synthetic-Integron-2010]
  2. Bouvier M, Ducos-Galand M, Loot C, Bikard D, and Mazel D. . pmid:19730680. PubMed HubMed [attC-2010]
  3. Bikard D, Patel D, Le Metté C, Giorgi V, Camilleri C, Bennett MJ, and Loudet O. . pmid:19179528. PubMed HubMed [Weak-Root-2009]
  4. Bikard D, Képès F, and L'Equipe iGEM Paris. . pmid:18466734. PubMed HubMed [iGEM-Paris-2007]
All Medline abstracts: PubMed HubMed

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