User:Tkadm30/Notebook/Research: Difference between revisions
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* | * Stress-induced neuroinflammation of the hippocampus/CNS | ||
* Glutamatergic system/neurotransmission | * Glutamatergic system/neurotransmission | ||
* Glutamate | ** Glutamate-induced excitotoxicity | ||
* Astrocytes/mitochondria | * Astrocytes/mitochondria | ||
** CB1 expression in hippocampal astrocytes and mitochondria | ** CB1 expression in hippocampal astrocytes and mitochondria | ||
* Intracellular DHA delivery to neurons | * Intracellular DHA delivery to neurons | ||
* Neuroprotective effects of P2X7 | * Neuroprotective effects of P2X7 agonists | ||
** Extracellular ATP releases | ** Extracellular ATP releases/ATP-mediated gliotransmission | ||
** | ** Effects of adenosine receptors on 2-AG mediated synaptic activity | ||
* Neuroprotection by endocannabinoids of the hippocampus | * Neuroprotection by endocannabinoids of the hippocampus | ||
** Adult hippocampal neurogenesis | ** Adult hippocampal neurogenesis regulation by CB1 receptor | ||
** Endocannabinoid-mediated neuroprotection | ** Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS | ||
* Intrinsic brain activity | |||
== Endocannabinoids as a novel therapeutic platform == | == Endocannabinoids as a novel therapeutic platform == | ||
Revision as of 12:16, 20 December 2015
Research Interests
- Stress-induced neuroinflammation of the hippocampus/CNS
- Glutamatergic system/neurotransmission
- Glutamate-induced excitotoxicity
- Astrocytes/mitochondria
- CB1 expression in hippocampal astrocytes and mitochondria
- Intracellular DHA delivery to neurons
- Neuroprotective effects of P2X7 agonists
- Extracellular ATP releases/ATP-mediated gliotransmission
- Effects of adenosine receptors on 2-AG mediated synaptic activity
- Neuroprotection by endocannabinoids of the hippocampus
- Adult hippocampal neurogenesis regulation by CB1 receptor
- Endocannabinoid-mediated neuroprotection against synthetic neurotoxicants of the CNS
- Intrinsic brain activity
Endocannabinoids as a novel therapeutic platform
The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoids platform for neurocognitive therapy.
Intracellular delivery of synaptamide to neurons by endocannabinoids
This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.
Synaptogenic effects of DHA on neurotransmission, a putative endocannabinoid induced by THC
P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.
