User:Etienne Robillard/Notebook/DHA

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DHA (docosahexaenoic acid)

Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing BDNF/CREB signaling

  • BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs)
  • Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation.
    • DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels
    • mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. [1]

Neuroprotective properties of DHA

  • DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [2]
  • DHA exert proneurogenic functions on activated microglia cells. [3]

DHA and vitamin D control of serotonin synthesis

DHEA (N-docosahexaenoyl ethanolamide)

  • Ethanolamide metabolite of DHA.
  • Derivative of anandamide.
  • A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [4]


Error fetching PMID 19812317:
Error fetching PMID 25504554:
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  1. Error fetching PMID 19812317: [Paper1]
    Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.

  2. Error fetching PMID 25504554: [Paper2]
    Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.

  3. Error fetching PMID 22057807: [Paper3]
    Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.



    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.

All Medline abstracts: PubMed HubMed

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