Taylor:Research: Difference between revisions
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== Solubility Enhancement == | == Solubility Enhancement == | ||
[[image:overviewASD.tif|thumb|500px|left|Fig. 1. Overview of important features of amorphous solid dispersions | [[image:overviewASD.tif|thumb|500px|left|Fig. 1. Overview of important features of amorphous solid dispersions]] | ||
Many important substances including new drugs, agricultural chemicals and nutraceuticals are often very insoluble in water. This can make them very hard to formulate and deliver and may even prevent new drugs from being clinically efficacious. Several strategies have emerged to improve aqueous solubility and drug delivery including salt formation, amorphous solid dispersions, cocrystals, complexation, lipid formulations and combinations thereof. The Taylor group is actively involved in research topics pertinent to solubility enhancement and how the different enhancement methods compare with one another. The group has considerable expertise with amorphous formulations, and amorphous solid dispersions are of particular interest. Research in this area encompasses all aspects of the design, production and characterization of amorphous solid dispersions as summarized in Fig. 1. | Many important substances including new drugs, agricultural chemicals and nutraceuticals are often very insoluble in water. This can make them very hard to formulate and deliver and may even prevent new drugs from being clinically efficacious. Several strategies have emerged to improve aqueous solubility and drug delivery including salt formation, amorphous solid dispersions, cocrystals, complexation, lipid formulations and combinations thereof. The Taylor group is actively involved in research topics pertinent to solubility enhancement and how the different enhancement methods compare with one another. The group has considerable expertise with amorphous formulations, and amorphous solid dispersions are of particular interest. Research in this area encompasses all aspects of the design, production and characterization of amorphous solid dispersions as summarized in Fig. 1. | ||
Revision as of 11:04, 3 January 2014
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