TB Breath Test Proposal: Difference between revisions
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'''Project Overview:''' | '''Project Overview:''' | ||
Developing a novel biosensor device to diagnose Tuberculosis infection ''quickly'' and ''efficiently'' | |||
'''Background''' | '''Background''' | ||
'' | |||
''Disease background'' | |||
-Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis | -Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis | ||
-can be fatal | -can be fatal | ||
-usually affects the lungs, but can also affect brain, kidneys, spine | -usually affects the lungs, but can also affect brain, kidneys, spine | ||
-symptoms include weight loss, night sweats, fever, chills, coughing (blood), chest pain | -symptoms include weight loss, night sweats, fever, chills, coughing (blood), chest pain | ||
-latent vs active infection | -latent vs active infection | ||
-becomes active if immune system cannot repress growth | -becomes active if immune system cannot repress growth | ||
-5-10% of latent cases will become active | -5-10% of latent cases will become active | ||
''-2 widely used current tests:'' | ''-2 widely used current tests:'' | ||
-Mantoux TB skin test injects a small amount of tuberculin into the skin | -Mantoux TB skin test injects a small amount of tuberculin into the skin | ||
-patient must return to clinic 48/72 hours later for evaluation of injection site | -patient must return to clinic 48/72 hours later for evaluation of injection site | ||
-TB blood test (interferon-gamma release assay) measures immune system reaction to TB bacteria | -TB blood test (interferon-gamma release assay) measures immune system reaction to TB bacteria | ||
Revision as of 19:41, 3 December 2013
20.109 WF Pink Team Research Proposal
TB Breath Test
Project Overview:
Developing a novel biosensor device to diagnose Tuberculosis infection quickly and efficiently
Background
Disease background
-Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis
-can be fatal
-usually affects the lungs, but can also affect brain, kidneys, spine
-symptoms include weight loss, night sweats, fever, chills, coughing (blood), chest pain
-latent vs active infection
-becomes active if immune system cannot repress growth
-5-10% of latent cases will become active
-2 widely used current tests:
-Mantoux TB skin test injects a small amount of tuberculin into the skin
-patient must return to clinic 48/72 hours later for evaluation of injection site
-TB blood test (interferon-gamma release assay) measures immune system reaction to TB bacteria
Problem/Goals Statement:
Details/Method:
Predicted Outcomes:
Resources:
