Imported:YPM/Yeast pheromone response model

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Category:Yeast Pheromone Response Model

Receptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste4Ste18Ste20Ste7Ptp3Msg5Ptp2Ste11/Ste50 interactionsSte11Ste50Fus3Fus3Kss1Kss1Ste5Ste5Dig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesisPheromone/Receptor interactionsPheromoneReceptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste18Ste4/Ste5 interactions and Ste5 dimerization/oligomerizationSte4/Ste20 interactionSte4Ste20Ste5/MAPK cascade interactionsSte11/Ste50 interactionsSte50Ste11Ste7Fus3MAPK phosphorylation cascadePtp3Msg5Ste5Fus3Kss1Fus3Kss1Ptp2Dig1/Dig2/Ste12 phosphorylationDig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesisPathway diagram 750px.png

Reactions

Receptor/G-Protein

Pheromone/Receptor/G protein interactions

G protein nucleotide hydrolysis/exchange

RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactions

Gβ(Ste4)/Gγ(Ste18) interaction

Fus3/Gpa1/Ste4 interactions

Synthesis/Degradation

Receptor(Ste2) synthesis/endocytosis/degradation

RGS(Sst2) synthesis/degradation

Gα(Gpa1) synthesis/degradation

Gpa1 synthesis/degradation
kdeg_Gpa1
ksynth_Gpa1

MAPK Cascade

Ste4:Ste18/Ste5 interactions and Ste5 dimerization/oligomerization

Ste4:Ste18/Ste20 interaction

Ste5/MAPK cascade interactions

MAPK phosphorylation cascade

MAPK/phosphatase interactions

Ste7/MAPK interactions

Ste11/Ste50 interactions

Synthesis/Degradation

Ste11 synthesis/degradation

Ste7 synthesis/degradation

Gene Expression

Dig1/Dig2/Ste12/Tec1 interactions

Dig1/Ste12 Interactions
kon_Ste12_Dig1
koff_Ste12_Dig1
kon_Ste12_Dig1PO4
koff_Ste12_Dig1PO4
kon_Ste12Dig2_Dig1
koff_Ste12Dig2_Dig1
kon_Ste12Dig2_Dig1PO4
koff_Ste12Dig2_Dig1PO4
kon_Ste12Kss1_Dig1
koff_Ste12Kss1_Dig1
kon_Ste12Kss1_Dig1PO4
koff_Ste12Kss1_Dig1PO4
kon_Ste12Kss1Dig2_Dig1
koff_Ste12Kss1Dig2_Dig1
kon_Ste12Kss1Dig2_Dig1PO4
koff_Ste12Kss1Dig2_Dig1PO4
kon_Ste12Fus3_Dig1
koff_Ste12Fus3_Dig1
kon_Ste12Fus3_Dig1PO4
koff_Ste12Fus3_Dig1PO4
kon_Ste12Fus3Dig2_Dig1
koff_Ste12Fus3Dig2_Dig1
kon_Ste12Fus3Dig2_Dig1PO4
koff_Ste12Fus3Dig2_Dig1PO4
Ste12_Dig1_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12_Dig1_Kss1_coop_factor
Ste12_Dig1_Fus3_coop_factor
Dig2/Ste12 Interactions
kon_Ste12_Dig2
kon_Ste12_Dig2PO4
kon_Ste12Dig1_Dig2
kon_Ste12Dig1_Dig2PO4
koff_Ste12_Dig2
koff_Ste12_Dig2PO4
koff_Ste12Dig1_Dig2
koff_Ste12Dig1_Dig2PO4
Ste12_Dig2_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12/Kss1 Interactions
kon_Ste12_Kss1
kon_Ste12_Kss1pT
kon_Ste12_Kss1pY
kon_Ste12_Kss1pTpY
kon_Ste12Dig1_Kss1
kon_Ste12Dig1_Kss1pT
kon_Ste12Dig1_Kss1pY
kon_Ste12Dig1_Kss1pTpY
koff_Ste12_Kss1
koff_Ste12_Kss1pT
koff_Ste12_Kss1pY
koff_Ste12_Kss1pTpY
koff_Ste12Dig1_Kss1
koff_Ste12Dig1_Kss1pT
koff_Ste12Dig1_Kss1pY
koff_Ste12Dig1_Kss1pTpY
Ste12_Kss1_pT_factor
Ste12_Kss1_pY_factor
Ste12_Kss1_pTpY_factor
Ste12_Dig1_Kss1_coop_factor
Ste12/Fus3 Interactions
kon_Ste12_Fus3
kon_Ste12_Fus3pT
kon_Ste12_Fus3pY
kon_Ste12_Fus3pTpY
kon_Ste12Dig1_Fus3
kon_Ste12Dig1_Fus3pT
kon_Ste12Dig1_Fus3pY
kon_Ste12Dig1_Fus3pTpY
koff_Ste12_Fus3
koff_Ste12_Fus3pT
koff_Ste12_Fus3pY
koff_Ste12_Fus3pTpY
koff_Ste12Dig1_Fus3
koff_Ste12Dig1_Fus3pT
koff_Ste12Dig1_Fus3pY
koff_Ste12Dig1_Fus3pTpY
Ste12_Fus3_pT_factor
Ste12_Fus3_pY_factor
Ste12_Fus3_pTpY_factor
Ste12_Dig1_Fus3_coop_factor

Dig1/Dig2/Ste12 phosphorylation

Ste12 mediated protein synthesis

Synthesis/Degradation

Tec1 synthesis/degradation
Ste12 synthesis/degradation

Other

Far1/MAPK interactions

Non-specific dephosphorylation

Protein dilution/synthesis due to cell growth

Cell cycle regulation of pheromone response

Pheromone-dependent cell cycle arrest

Parameter Constraint Assumption Pages

MAPK/target interaction properties
Ste2/Gpa1/Ste4:Ste18 binding rate constant constraints
Ste5 dimerization and Ste4 binding rate constant constraints
Dig1/Dig2/Ste12/MAPK binding rate constant constraints

Elemental Species

Cell
Dig1
Dig2
Far1
Fus3
Gpa1
Kss1
Msg5
Pheromone
Ptp2/Ptp3
Sst2
Ste2
Ste4:Ste18
Ste5
Ste7
Ste11
Ste12
Ste20
Yck

Species not included in model

Bem1
Bni1
Cdc24
Cdc28
Cdc42
Fus1
Hog1
Pbs2
Prm1
Spa2
Ste50
Tec1

Phenomenology

Localization effects

Page Categories

Yeast Pheromone Response Model
Reactions - Yeast Pheromone Response Model
Parameters - Yeast Pheromone Response Model
Species - Yeast Pheromone Response Model