Imported:YPM/Yck

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< Imported:YPM(Redirected from Imported:YPM/Yck2)

Category:Species - Yeast Pheromone Response Model Back to main model page



General Comments

  • Yck1, Yck2 and Yck3 are serine/threonine protein kinase
  • Part of the Casein Kinase I (CKI) family. Wu et al. 2003 PMID 14555477
  • All three Yck proteins have a similar specific activity on casein. Sternbach and Kuntzel 1987 PMID 3311146
  • Yck1 and Yck2 proteins are required for the phosphorylation, ubiquitinylation and internalization of Ste2. Hicke et al. 1998 PMID 9548714
  • The canonical CKI target consensus sequence is (D/E)1-3-X-X-S/T. Wu et al. 2003 PMID 14555477

Yck1

  • Potential palmitoylation sites at C537 and C538. Swiss-Prot
  • Yck1 strongly prefers ATP as phosphate source. Sternbach and Kuntzel 1987 PMID 3311146

Yck2

  • Palmitoylated at C545 and C546 by Akr1(required for membrane localization). Roth et al. 2002 PMID 12370247
  • [Yck2]] strongly prefers ATP as phosphate source. Sternbach and Kuntzel 1987 PMID 3311146

Yck3

  • Potential geranyl-geranylation sites at C523 and C524. Swiss-Prot
  • Yck3 is able to use both ATP and GTP efficiently as phosphate sources. Sternbach and Kuntzel 1987 PMID 3311146
  • Yck3 has a kcat = 2.4 /s for casein target (Sternbach et al., Biochem (26) 4207)
  • Appears not to be important for adaptation in pheromone response. Hicke et al. 1998 PMID 9548714

Reactions

Receptor(Ste2) synthesis/endocytosis/degradation
Protein dilution/synthesis due to cell growth

Species Representation

Molecule Type

<modelMoleculeType>Yck(Ste2_site)</modelMoleculeType>

Model Seed

<modelSeedSpecies>Yck(Ste2_site) Yck_tot_conc</modelSeedSpecies>