Imported:YPM/MAPK pY only Kd factor

From OpenWetWare
Jump to navigationJump to search

Category:Parameters - Yeast Pheromone Response Model Back to main model page



<modelParameter>MAPK_pY_only_Kd_factor = 2</modelParameter>

Definition

This is the factor by which phosphorylation of Fus3 or Kss1 on just the tyrosine decreases its affinity for a target, compared to the affinity of doubly phosphorylated Fus3 or Kss1 for that same target.
Kd_MAPKpY_target = MAPK_pY_only_Kd_factor * Kd_MAPKpTpY_target
MAPK_pY_only_Kd_factor > 1 means that MAPKpY binds its targets more weakly than MAPKpTpY.

Source

  • Experimentally measured for ERK2 phosphorylation of MBP and ELK1.

Trust

  • Medium

Additional Details

See MAPK/target interaction properties for more details.