User talk:Jeremy S. Myers
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The human proteome is the protein complement of human genome, the primary functional components of a cell, and key to understanding human disease.
Proteomics is the analysis of proteins that make-up the proteome and employs various advanced biotechnologies to understand the dynamic regulation of the proteome.
Mass spectrometry-based analysis is the prevailing tool for proteomics and has the potential to identify indicators of disease, identify targets for treatment, and monitor treatment response. Many different mass spectrometry proteomics platforms exist. Global proteomic analyses are the prominent platforms applied in cancer proteomics. They attempt to identify and quantitate a maximum number of proteins. However, these platforms face a number of challenges:
1. Global protein identification is dependent on the relative abundance of proteins in the proteome. Many regulatory changes in the proteome that define cell activity are relatively low abundant protein modifications.
2. Genetic differences between individuals and within in each of the trillions of cells the body, which mutate at an estimated 10,000 mutations in each cell per day, complicate the identification of proteins important in disease
Targeted proteomics addresses these challenges by targeting the fraction of the proteome most relevant to disease.
Leveraging diverse research experience and advanced mass spectrometry-based proteomics, we are providing new insight to human disease.
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