User:Genome Data Description
(Redirected from User:Yuedongyang/Notebook/Genome Data Description)Jump to navigationJump to search
CCLE (Cancer Cell Line Encyclopedia): Yangyd
The CCLE (Cancer Cell Line Encyclopedia) project is a collaboration between the Broad Institute, and the Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer patient stratification. The CCLE provides public access to genomic data, analysis and visualization for over 1100 cell lines. Gene expression data can be visualized as box plots or compared to other expression values in scatter plots. Each gene has multiple datasets and data identifiers. The five major dataset types are Copy Number, mRNA expression (Affy), RPPA, RRBS, and mRNA expression (RNAseq). Gene Methylation can also be visualized through a bubble map. Mutation data for individual cell lines is viewable and downloadable.