User:Yeu Chun Kim

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Yeu Chun Kim (an artistic interpretation)
  • Yeu Chun Kim
  • Assistant Professor
  • Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)
  • 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea
  • dohnanyi@kaist.ac.kr

Education & Professional Experiences

Educaton

  • 2007, PhD, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology
  • 2001, MS, Department of Chemical and Biomolecular Engineering, KAIST
  • 1999, BS, Department of Chemical and Biomolecular Engineering, Yonsei University

Professional Experiences

  • 2011, Senior Research Engineer,Biotechnology Process Engineering Center, KRIBB (Korea Research Institute of Bioscience and Biotechnology)
  • 2011, Research Faculty, Division of Nano Sciences, Ewha Womans University
  • 2009-2010, Visiting Scholar, Department of Microbiology and Immunology, Emory University School of Medicine
  • 2008-2010, Post-doctoral Research Fellow, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology
  • 2002-2007, Research Assistant, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology
  • 2002-2006, Teaching Assistant, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology
  • 2000-2001, Visiting Researcher, Biotechnology Process Engineering Center, KRIBB (Korea Research Institute of Bioscience and Biotechnology)

Research interests

  • Drug delivery (Transdermal, Pumonary, Intranasal, Oral)
  • Gene therapy (DNA vaccine delivery, siRNA delivery, gene correction)
  • Biomedical device (Microneedle & Nanoneedle technology, Electroporation, Sonoporation, Iontophoresis)
  • Vaccine research (Effective vaccination, Mass production of recombinant vaccine, Vaccine adjuvant, Veterinary vaccine)
  • Antimicrobial peptide research (Skin permeation enhancer, Gene delivery, Adjuvant)

Publications

  • 1. S.J.Kim, H.J.Shin, Y.C.Kim, D.S.Lee, J.W.Yang (2000) Isolation and purification of methyl mercaptan oxidase from Rhodococcus rhodochrous for mercaptan detection, Biotechnology and Bioprocess Engineering 5 : 465-468.
  • 2. Y.C.Kim, P.Ludovice, M.Prausnitz (2007) Transdermal delivery enhanced by magainin pore-forming peptide, Journal of Controlled Release 22 : 375-383.
  • 3. Y.C.Kim, J.H.Park, P.Ludovice, M.Prausnitz (2008) Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol, International Journal of Pharmaceutics 352 : 129–138.
  • 4. Y.C.Kim, P.Ludovice, M.Prausnitz (2008) Optimization of transdermal delivery using magainin pore-forming peptide, Journal of Physics and Chemistry of Solids 69 : 1560-1563.
  • 5. J.H.Park, J.W.Lee, Y.C.Kim, M.R.Prausnitz (2008) The effect of heat on skin permeability, International Journal of Pharmaceutics 359 : 94-103.
  • 6. Y.C.Kim, S.Late, A.Banga, P.Ludovice, M.Prausnitz (2008) Biochemical enhancement of transdermal delivery with magainin peptide: Modification of electrostatic interactions by changing pH, International Journal of Pharmaceutics 362 : 20-28.
  • 7. F.S.Quan, Y.C.Kim*, D.G.Yoo, R.W.Compans, M.R.Prausnitz, S.M.Kang (2009) Stabilization of influenza vaccine enhances protection by microneedle delivery in the skin, Plos ONE 4 : e7152.
  • 8. Y.C.Kim, F.S.Quan, D.G.Yoo, R.W.Compans, S.M.Kang, M.R.Prausnitz (2009) Improved influenza vaccination in the skin using vaccine coated-microneedles, Vaccine 27 : 6932-6938.
  • 9. Y.C.Kim, F.S.Quan, D.G.Yoo, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Enhanced memory responses to H1N1 influenza vaccinationin the skin using vaccine coated-microneedles, Journal of Infectious Disease 201 : 190-198.
  • 10. Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity, Journal of Controlled Release 142 : 187-195.
  • 11. S.O.Choi, Y.C.Kim, J.H.Park, J.Hutcheson, H.S. Gill, Y.-K. Yoon, M.R. Prausnitz, and M.G. Allen (2010) An electrically active microneedle array for electroporation, Biomedical Microdevices 12 : 263-273.
  • 12. Y.C. Kim, F.S.Quan, J.M.Song, A.Vunnava, D.G.Yoo, K.M. Park, R.W.Compans, S. M. Kang, M. R. Prausnitz (2010) Microscale-needles immunization with stabilized H1N1 influenza virus-like particle vaccine, Procedia in Vaccinology 2: 17-21.
  • 13. F.S.Quan, Y.C.Kim*, A. Vunnava, D.G.Yoo, J.M.Song, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Intradermal vaccination with influenza VLPs using microneedles induces superior protection to intramuscular immunization, Journal of Virology 84 : 7760-7769.
  • 14. M.Pearton, S.M.Kang, J.M.Song, Y.C.Kim, F.S.Quan, M.Ivory, R.W.Compans, M.R.Prausnitz, J.C.Birchall (2010) Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin, Vaccine 28 : 6104-6113.
  • 15. J.M.Song, Y.C.Kim, A.S.Lipatov, M.Pearton, C.T.Davis, K.M.Park, L.M.Chen, F.S.Quan, J.Birchall, R.O.Donis, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Microneedle delivery of virus-like particles to the skin induces long-lasting protective immunity against H5N1 influenza virus, Clinical and Vaccine Immunology 17 : 1381-1389.
  • 16. Y.C.Kim, P.Ludovice, M.Prausnitz (2010) Transdermal delivery enhanced by antimicrobial peptides, Journal of Biomedical Nanotechnology, 6 : 612-620.
  • 17. Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2010) Fomulation of microneedles coated withvirus-like particle influenza vaccine, AAPS PharmSciTech, 11 : 1193-1201
  • 18. F.S.Quan, Y.C.Kim*, R.W.Compans, M.R.Prausnitz, S.M.Kang (2010) Dose sparing microneedles vaccination with H1 influenza VLPs, Journal of Controlled Release, 147 : 326-332.
  • 19. J.M.Song, Y.C.Kim, P.G.Barlow, M.J.Hossain, K.M.Park, R.O.Donis, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Improved protection against avian influenza H5N1 virus by a single vaccinationwith virus-like particles in skin using microneedles, Antiviral Research, 88 : 244-247.
  • 20. Y.C.Kim, F.S.Quan, R.W.Compans, S.M.Kang, M.R.Prausnitz (2011) Long-term storage and stability kinetics of influenza vaccines using coated microneedle, Pharmaceutical Research, 28 : 135-144.
  • 21. Y.C.Kim, M.R.Prausnitz (2011) Enabling skin vaccination using new delivery technologies, Drug Delivery and Translational Research, 1:7-12.
  • 22. Y.Hiraishi, S.Nandakumar, S.O.Choi, J.W.Lee, Y.C.Kim, J.E.Posey, S.B.Sable, M.R. Prausnitz (2011) Bacillus Calmette-Guérin (BCG) vaccination using a microneedle patch, Vaccine, 29 : 2626-2636.
  • 23. E.G.González, Y.C.Kim, T.J.Speaker, R.P.Hickerson, R.Spitler, J.C.Birchall, M.F.Lara, R.Hu, Y.Liang, N.K.Smith, M.R.Prausnitz, C.H.Contag, L.M.Milstone, R.L.Kaspar (2011) Visualization of plasmid delivery to keratinocytes in mouse and human epidermis, Scientific Reports, 1:158.
  • 24. Y.C.Kim, D.Zehrung, J.Courtney, S.Mitragotri, M.R.Prausnitz (2012) Delivery systems for intradermal vaccination, Current Topics in Microbiology and Immunology, 351 : 77-112
  • 25. S.O.Choi, Y.C.Kim, J.W.Lee, J.H.Park, M.R.Prausnitz, M.G.Allen (2012) An electrically active microneedle array for electroporation , Small, accepted.
                  * Equally contribution. Co-first author.

Presentations

Invited Talks

  • 1. Y.C.Kim (2008) Formulation of self-administered microneedle patches for influenza vaccines, IBC Formulation strategies for Protein Therapeutics conference (Anaheim, CA, USA)
  • 2. Y.C.Kim (2009) Microneedle patches for improved influenza vaccination, Medical materials and technologies conference (Greenville, SC, USA)
  • 3. Y.C.Kim (2009) DNA delivery using coated microneedle patch, IPCC (International Pachyonychia Congenita Consortium) symposium (Montreal, CANADA)
  • 4. Y.C.Kim (2009) Self-administratable influenza vaccination using coated microneedles, Korea Research Institute for Bioscience & Biotechnology (KRIBB, Daejeon, KOREA) Seminar
  • 5. Y.C.Kim (2009) Self-administratable influenza vaccination using coated microneedles, Korea Advanced Institute of Science and Technology (KAIST, Daejeon, KOREA) Young Investigator Seminar
  • 6. Y.C.Kim (2010) Delivery system design and formulation of microneedles, Short Course, 1st International Conference on Microneedles (Atlanta, GA, USA)
  • 7. Y.C.Kim (2011) Transdermal delivery by microneedle, Handok pharmaceuticals co.(Seoul, KOREA) Invited Seminar
  • 8. Y.C.Kim (2011) Self-administratable influenza vaccination using coated microneedles, Polymer Society of Korea (Kwangju, KOREA) Society's Fall Meeting
  • 9. Y.C.Kim (2011) Self-administered influenza vaccination using coated microneedles, Korea Basic Science Institute (Deajeon, KOREA) Invited Seminar
  • 10. Y.C.Kim (2011) Self-administered influenza vaccination using coated microneedles, Chungnam National University, School of Medicine (Deajeon, KOREA) Invited Seminar
  • 11. Y.C.Kim (2011) Microneedle Patches for Improved Influenza Vaccination, Korean Society for Biomaterials (Seould, KOREA) Presentation in Young Scientists Forum of Biomaterial Research
  • 12. Y.C.Kim (2011) Self-administered influenza vaccination using coated microneedles, College of Veterinary Medicine, Konkuk University (Seoul, KOREA) Invited Seminar
  • 13. Y.C.Kim (2011) Microneedle Patches for Improved Influenza Vaccination, MOGAM Biotechnology Research Institute (Gyeonggi, KOREA) Invited Seminar
  • 14. Y.C.Kim (2011) Microneedle Patches for Improved Influenza Vaccination, Korea Institute of Science and Technology (KIST, Seould, KOREA) ) Invited Seminar
  • 15. Y.C.Kim (2011) Microneedle Patches for Improved Influenza Vaccination, Yonsei University, Department of Biotechnology (Seoul, KOREA) Invited Seminar
  • 16. Y.C.Kim (2011) Self-administered influenza vaccination using coated microneedles, Chungnam National University, Department of Biochemistry (Deajeon, KOREA) Invited Seminar
  • 17. Y.C.Kim (2011) Microneedle Patches for Improved Influenza Vaccination, Department of Electronic Engineering, College of Electronics and Information Engineering, Kwangwoon University (Seoul, KOREA) Invited Seminar

Conference

  • 1. Y.C.Kim, J.W.Yang, J.K.Jung (2001) Optimization of gfermentation for polysaccharide (β- glucan) production, The Korean Society for Microbiology and Biotechnology Annual Meeting (Korea)
  • 2. Y.C.Kim, P.J.Ludovice, M.R. Prausnitz (2004) Peptide enhancement of electrically-driven transdermal drug delivery, Suddath Symposium, Georgia Institute of Technology (Atlanta, GA, USA)
  • 3. Y.C.Kim, P.J.Ludovice, M.R.Prausnitz (2005) Synergistic enhancement of transdermal delivery using a pore-forming peptide and chemical enhancer, Suddath Symposium, Georgia Institute of Technology (Atlanta, GA, USA)
  • 4. S.O.Choi, J.H.Park, Y.C.Kim, H.S.Gill, M.G.Allen, M.R.Prausnitz (2005) Microneedle electrode array for electroporation of skin for gene therapy, Controlled Release Society Meeting (Miami, FL, USA)
  • 5. Y.C.Kim, P.J.Ludovice, M.R.Prausnitz (2005), Synergistic enhancement of transdermal delivery using a pore-forming peptide and chemical enhancer, Controlled Release Society Meeting (Miami, FL, USA)
  • 6. S.O.Choi, J.H.Park, Y.Choi, Y.C.Kim, H.S.Gill, Y.K. Yoon, M.R. Prausnitz, M.G. Allen (2005) An electrically active microneedle array for electroporation of skin for gene delivery, Transducers (Seoul, Korea)
  • 7. Y.C.Kim, P.Ludovice, M.Prausnitz (2006) Synergistic enhancement of transdermal delivery using a pore-forming peptide and chemical enhancer, ACS meeting (Atlanta, GA, USA)
  • 8. Y.C.Kim, P.Ludovice, M.Prausnitz (2006) Mechanistic analysis of increased skin permeability using a pore-forming peptide and chemical enhancer, Controlled Release Society Meeting (Vienna, Austria)
  • 9. J.H.Park, J.W.Park, Y.K.Yoon, J.W.Lee, S.O.Choi,Y.H.Joung, R.Kamath, Y.C.Kim, M.G. Allen, M.R. Prausnitz (2006) Wireless induction heating of stratum corneum for transdermal drug delivery, AIChE meeting (San Fransisco,CA, USA)
  • 10. Y.C.Kim, S.Late, A.Banga P.Ludovice, M.Prausnitz (2007) Optimization of transdermal delivery using magainin pore-forming peptide, ISIC meeting (Seoul, Korea)
  • 11. Y.C.Kim, S.Late, G.Thorsteinson, A.Pate, A.Banga, P.Ludovice, M.Prausnitz (2007) Transdermal drug delivery enhanced by magainin pore-forming peptide: modification of electrostatic interactions by changing pH, Controlled Release Society Meeting (Los Angelis, CA, USA)
  • 12. S.O.Choi, Y.C.Kim, J.Hutcheson, J.W.Lee, M.G.Allen, M.R.Prausnitz (2008) A polymeric electroporation microneedle array for enhanced intracellular delivery, MicroTAS meeting (San diego, CA, USA)
  • 13. Y.C.Kim, S.Late, A.Banga, P.Ludovice, M.Prausnitz (2008) Transdermal drug delivery enhanced by magainin pore-forming peptide, AIChE meeting (Philadelpia, PA, USA)
  • 14. Y.C.Kim, S.O.Choi, M.G.Allen, M.R.Prausnitz (2008) A polymeric electroporation microneedle array for minimally invasive and highly localized electrogenetherapy, AIChE meeting (Philadelpia, PA, USA)
  • 15. Y.C.Kim, F.S.Quan, V.Zarnitsyn, H.S.Gill, I.Skountzou, C.Yang, S.M.Kang, R.Compans, M.Prausnitz (2008) Microneedle-based immunization against influenza, AIChE meeting (Philadelpia, PA, USA)
  • 16. Y.C.Kim, F.S.Quan, R.Compans, S.M.Kang, M.Prausnitz (2009) Microneedle patches for improved influenza vaccination, Controlled Release Society Meeting (Copenhagen, Denmark)
  • 17. F.S.Quan, Y.C.Kim,, A.Vunnava, D.G.Yoo, M.Prausnitz, R.Compans, S.M.Kang, (2009) Vaccination with influenza VLPs in the skin using microneedles induces protection, Annual Meeting on the Immunobiology of Influenza Virus Infection (Athens, GA, USA)
  • 18. J.M Song, Y.C.Kim,, A.S.Lipatov, D.G.Yoo, T.Davis, K.M.Park, L.M.Chen, R.O.Donis, M.Prausnitz, R.Compans, S.M.Kang, (2009) Delivery of H5 virus-like particles to the skin using microneedles induces protective immunity against H5N1 influenza virus, Annual Meeting on the Immunobiology of Influenza Virus Infection (Athens, GA, USA)
  • 19. Y.C.Kim, F.S.Quan, J.M Song, D.G.Yoo, R.Compans, S.M.Kang, M.Prausnitz (2009) Improved intradermal immunization using influenza VLP-coated microneedles, 3rd Vaccine Global Congress (Singapore)
  • 20. Y.C.Kim, J. Birchall, M.Prausnitz (2010) Microneedle patches for GO Delivery project, Stanford GO Delivery Skin Symposium (San Fransisco, CA, USA)
  • 21. Y.C.Kim, F.S.Quan, D.G.Yoo, R.Compans, S.M.Kang, M.Prausnitz (2010) Immunogenicity and stability of inactivated influenza virus vaccine administered using coated microneedles, 1st International Conference on Microneedles (Atlanta, GA, USA)
  • 22. Y.C.Kim, F.S.Quan, R.Compans, S.M.Kang, M.Prausnitz (2010) Improved vaccination and dose-sparing effect of microneedles coated with influenza VLP vaccine, 1st International Conference on Microneedles (Atlanta, GA, USA)
  • 23. M.Pearton, S.M.Kang, J.M.Song, Y.C.Kim, F.S.Quan, M.Ivory, M.R.Prausnitz, R.W.Compans, J.C.Birchall (2010) Human skin model for the assessment of microneedle delivered influenza VLP vaccines, 1st International Conference on Microneedles (Atlanta, GA, USA)
  • 24. J.M.Song, Y.C.Kim, K.M.Park, M.R.Prausnitz, R.W.Compans, S.M.Kang (2010) Microneedle vaccination with virus-like particles induces enhanced cross protection against H5N1 avian influenza virus, 1st International Conference on Microneedles (Atlanta, GA, USA)
  • 25. Y.C.Kim, F.S.Quan, R.Compans, S.M.Kang, M.Prausnitz (2010) Dose sparing effect by influenza H1 VLP immunization using coated microneedles, Controlled Release Society Meeting (Portland, USA)
  • 26. Y.C.Kim, J.M Song, R.Compans, S.M.Kang, M.Prausnitz (2010) Influenza vaccination with H5 DNA coated microneedles, Controlled Release Society Meeting (Portland, USA)
  • 27. M.Pearton, S.M.Kang, J.M.Song, Y.C.Kim, F.S.Quan, M.Ivory, M.R.Prausnitz, R.W.Compans, J.C.Birchall (2010) Immune stimulation following microneedle delivery of influenza virus-like particle (VLP) vaccines to human skin, 3rd International Symposium for Cellular Delivery of Therapeutic Macromolecules (Cardiff, UK)
  • 28. Y.C.Kim, F.S.Quan, D.G.Yoo, R.Compans, S.M.Kang, M.Prausnitz (2010) Immunogenicity and stability of inactivated influenza virus vaccine administered using coated microneedles, AAPS Annual Meeting and Exposition (New Orleans, LA, USA)
  • 29. Y.C.Kim, F.S.Quan, R.Compans, S.M.Kang, M.Prausnitz (2010) Dose sparing of influenza vaccine using microneedles, Georgia Institute of Technology Industry Partners Symposium (Atlanta, GA, USA)
  • 30. E.G.González, Y.C.Kim, T.J.Speaker, R.P.Hickerson, R.Spitler, J.C.Birchall, M.F.Lara, R.Hu, Y.Liang, N.K.Smith, M.R.Prausnitz, L.Milstone, C.H.Contag, R.L.Kaspar (2011) Delivery and visualization of functional nucleic acids to mouse and human epidermis, Society for Investigative Dermatology (SID) Annual Meeting (Phoenix, AZ,USA)
  • 31. S.M.Kang, J.M.Song, F.S.Quan, Y.C.Kim, R.O.Donis, M.R.Prausnitz, R.W. Compans (2011) Long-term and cross-protective influenza immunity with novel virus-like particle vaccines, 5h Vaccine Global Congress (Seattle, WA, USA)
  • 32. E.G.González, Y.C.Kim, T.J.Speaker, R.P.Hickerson, R.Spitler, J.C.Birchall, M.F.Lara, R.Hu, Y.Liang, N.K.Smith, M.R.Prausnitz, L.Milstone, C.H.Contag, R.L.Kaspar (2011) Visualization of functional nucleic acid delivery to mouse and human epidermis, World Molecular Imaging Congress (San Diego, CA,USA)
  • 33. M.Pearton, S.M.Kang, J.M.Song, Y.C.Kim, F.S.Quan, M.Ivory, V.Saller, S.Coulman R.W.Compans, M.R.Prausnitz, J.C.Birchall (2011) Microneedle delivery of influenza virus-like particle (VLP) and DNA vaccines to live human skin model, Skin Vaccination Summit 2011 (Washington DC, USA)
  • 34. S.M.Kang, J.M.Song, F.S.Quan, Y.C.Kim, R.O.Donis, M.R.Prausnitz, R.W. Compans (2011) Skin vaccination using microneedles with inactivated influenza virus, recombinant virus-like particles, or plasmid DNAs induces improved protective immunity, Skin Vaccination Summit 2011 (Washington DC, USA)
  • 35. Y.C.Kim, J.M Song, D.G.Yoo, R.Compans, S.M.Kang, M.Prausnitz (2011) DNA vaccination against influenza using coated microneedles, Skin Vaccination Summit 2011 (Washington DC, USA)