User:Thomas J. Rosol
- Thomas J. Rosol, DVM, PhD
- Professor of Veterinary Biosciences
- Special Assistant to the Senior Vice President for Technology Licensing & Commercialization
- Diplomate, American College of Veterinary Pathologists
- College of Veterinary Medicine
- The Ohio State University
- 1925 Coffey Road
- Columbus, OH 43210 USA
- College webpage: http://www.vet.ohio-state.edu/ThomasRosol.htm
- Curriculum vitae and publications: http://myprofile.cos.com/rosolt36
- Email: firstname.lastname@example.org
I've joined OpenWetWare to share lab information and protocols.
- Ph.D., Ohio State University, Experimental Pathobiology, 1986
- D.V.M., University of Illinois, Veterinary Medicine (Valedictorian, 1st of 86 Students), 1981
- B.S., University of Illinois, Veterinary Medicine (Highest Honors), 1979
- B.S., University of Illinois, Agricultural Science (Highest Honors), 1978
- See: http://myprofile.cos.com/rosolt36
- Thomas J. Rosol, DVM, PhD served as the Dean of the College of Veterinary Medicine (2005-2008) and currently serves as a Special Assistant to the Senior Vice President for Research for Technology Licensing and Commercialization. He is a Professor of Veterinary Pathobiology in the Department of Veterinary Biosciences in the OSU College of Veterinary Medicine.
- Dr. Rosol maintains an active, NIH-funded research laboratory that uses molecular, in vitro, and in vivo techniques to investigate the pathogenesis of human and animal cancers. Specifically, the laboratory develops mouse models of cancer to study the pathogenesis of bone metastasis, cancer-associated hypercalcemia, and human HTLV-1-induced T-cell lymphoma. The molecular regulation of parathyroid hormone-related protein is studied in vitro and in vivo using animal models of prostate, lung, and breast cancer, and lymphoma. Breast and prostate cancer both metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol laboratory has developed mouse models of human cancer that mimic metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. New laboratory expertise has been developed for in vivo imaging of cancer in mouse models using bioluminescence, high resolution ultrasound, and near infrared imaging of molecular markers. The lab is also examining the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers.
- PARATHYROID HORMONE-RELATED PROTEIN (PTHrP):
Pathogenesis in humoral hypercalcemia of malignancy Regulation in normal and neoplastic keratinocytes Regulation in lactation and mammary carcinomas Development of PTHrP knockout and knockin Mice Regulation of mRNA expression and stability Role in cancer metastases in bone Role in bone resorption associated with Human T-Lymphotropic-I Virus infection and canine lymphoma Regulation of PTHrP mRNA expression by Tax and HTLV-1 virus
- ANIMAL MODELS OF HUMAN DISEASE:
Paraneoplastic Syndromes Endocrinology Bone Disease, Bone Remodeling, Bone Metastasis Prostate Cancer and Osteoblastic Metastasis Breast, Lung, and Head & Neck Cancer and Osteolytic Bone Metastasis