User:TheLarry/Notebook/Larrys Notebook/2009/10/09

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Head can't bind to the microtubule if no ATP in bound head

Block/Guydosh said something to the effect that no matter how much force they put on the head they couldn't get it to bind to the microtubule without an ATP in the bound back head. So I try to get this in the simulation by lowering all the rate constants associated with binding in front without ATP in the other head, and with this change the kinesin walks backwards. Yeah i am having a hell of a time to get this thing walking forward with this stipulation. I don't know if i am just not thinking correctly about this or what, but this is a pain in the ass.