# User:TheLarry/Notebook/Larrys Notebook/2009/09/07/Force Dependence

< User:TheLarry‎ | Notebook‎ | Larrys Notebook‎ | 2009‎ | 09‎ | 07
ughh. that 1997 is an easier read but doesn't give me what i want. i am returning to Schnitzer Block of 2000. I am being strongly tempted just to use Bell's equation $\displaystyle{ k=k_0e^{\tfrac{-Fd}{k_BT}} }$. if only i knew where Scnitzer and Block got their funky looking equations. i just don't trust what Block is doing in this paper is what I want. I feel like he is looking at an overall change in rate and not just of a single off rate. It looks like that is right. That he just uses Bell equation above and solves the differential equation over how many states there are and gets his weird equation. So it seems to be for the overall path not just a state. A paper from Block's lab gave me this insight. The title is "Force and Velocity Measured for Single Molecules of RNA Polymerase." They look at RNAP but there is a section pseudo-deriving the equations from Schnitzer. In this paper there is also a quick explanation of how rebinding might be affected by force. Again it is bell equation but with a different term in for d. a Δ-d where Δ is the difference between the states. (In case you are looking at the paper, my variables are a bit different since i wrote my bell equation above before finding this paper)
Ok right now i am gonna say this is my idea until Koch tells me differently. I am liking this though. It is simple and seems to make sense to me. This page is getting kind of long so i'll just say summarily here that after looking through not a lot of literature I think i'll go with bell's equation. $\displaystyle{ k_\pm=k_{\pm,0}e^{\mp\tfrac{Fd_\pm}{k_BT}} }$. alright i am sure i'll try to find reasons why that is wrong later