User:Sterling G. Smith/Notebook/CFTR protein degradation and misfolding

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The most common autosomal recessive genetic disease is Cystic Fibrosis. This disorder arises by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). To discover the basis of Cystic Fibrosis we must completely understand the whole of CFTR biogenesis, folding and ultimately degradation.

Does natural selection favor high levels of chaperones? "an increase in mutational load selects for a concurrent increase in the cellular level of chaperones" (brodsky)